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adverse events allele analysis approach approval assess association baseline bias blood pressure cancer cardiovascular case-control study causal chapter Clin clinical research clinical trials cohort studies compared confounding control group controlled trials coronary discussed disease double-blind DSMB efficacy Epidemiology estimate ethical evaluate evidence example exposure factor frequency gene genetic haplotypes hypertension implementation research important improvement increase individual intervention investigators issues JAMA measure Medicine mentor meta-analysis methods monitoring multiple myocardial infarction null hypothesis observational studies occur odds ratio outcome p-value participants patients performed pharmacovigilance phase phenotype physician placebo controls placebo effect placebo group population postmarketing potential publication bias question randomized trials RCTs recruitment regression relative risk reported response rofecoxib safety sample selection significant SNPs specific standard statistical power study design subgroup subjects surrogate endpoints Table therapy tion treatment Type II error variable
Page 5 - The consequence was, that the most sudden and visible good effects were perceived from the use of the oranges and lemons ; one of those who had taken them, being at the end of six days fit for duty.