Imidazole and Benzimidazole Synthesis (Google eBook)
Imidazole and Benzimidazole Synthesis is a comprehensive survey of the known methods of syntheses and ring modification. It brings together the multitude of synthesis of the imidazole ring in a systemic way interms of specific bond formation, and recommends the most attractive synthetic approaches. It also collects non-ring-synthetic approaches to classes of compounds such as nitro-, halogeno-, and amino-imidazoles, and covers the synthesis of N-substituted compounds and preparations of specific isomers.
* The only book in print dealing specifically with this topic
* Comprehensive survey of the known methods of synthesis and ring modification
* Recommends the most attractive synthetic approaches
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0-phenylenediamine 2-substituted A. R. Katritzky Abstr acetic acid acetonitrile acyl added dropwise aldehyde alkyl amidine amino ammonia aqueous aryl benzene benzimidazole bromide carbon carboxylic catalytic Chem Chim chloride chloroform chromatography Compd compounds converted cooled cyclization derivatives dichloromethane diethyl ether difﬁcult dissolved distilled dried MgSO4 electrophilic ester ethanol ethyl acetate extracts are dried ﬁltered ﬁltrate formation formed give the product heated under reﬂux Heterocycl hexane high yields hydrochloric acid hydrochloride hydrogen imidate imidazoles ketone M. R. Grimmett method mixture is stirred mmol n-butyllithium N-oxides nitrile nitrogen nucleophilic oxidation Perkin Trans phenylenediamine potassium precipitate presence puriﬁed react reaction mixture readily reagent recrystallized reduced pressure residue ring room temperature rotary evaporated salts Scheme Section silica gel Similarly prepared sodium hydroxide solid stirred at room stirred solution substituted substrates synthesis synthetic Tetrahedron Lett TOSMIC Transl triethylamine USSR Engl washed with water yield given
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