Prodrugs and Targeted Delivery: Towards Better ADME Properties (Google eBook)

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Jarkko Rautio
John Wiley & Sons, Jan 11, 2011 - Medical - 520 pages
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This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs.
Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.
  

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Contents

I
1
II
3
III
31
IV
61
V
79
VI
81
VII
111
VIII
133
XII
231
XIII
253
XIV
271
XV
345
XVI
347
XVII
385
XVIII
415
XIX
417

IX
153
X
181
XI
207
XX
453
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About the author (2011)

Jarkko Rautio is professor of pharmaceutical chemistry and head of the multidisciplinary Pharmaceutical and Medicinal Chemistry (PMC) research group at the School of Pharmacy, University of Eastern Finland (formerly University of Kuopio), where he received his PhD in pharmaceutical chemistry in 2000. He subsequently carried out his postdoctoral studies at the University of Maryland, Baltimore, USA, and was a visiting scientist at GlaxoSmithKline, North Carolina, while also co-founding the American Association of Pharmaceutical Scientists (AAPS) Prodrug Focus Group in 2005. Professor Rautio's research focuses on chemistry-based methods, especially prodrugs, to overcome the liabilities of drugs.

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