Apoptosis and cancer chemotherapy
John A. Hickman, Caroline Dive
Humana Press, 1999 - Medical - 342 pages
This collection of thoughtful and provocative articles focused on the key issues in apoptosis, ranges from the role of apoptosis in defining the response of authentic tumor populations to chemotherapeutic agents to the mechanisms coupling DNA damage to the activation pathway of apoptosis. It reviews the profusion of new signaling, modulating, and effector molecules now implicated in apoptosis and whether other routes to "programmed" cell death may exist. Also addressed are the nature of the molecules that will either constitute targets for future drugs or influence the efficacy of current therapies, as well as mechanistic questions on the control of apoptosis. By focusing on essential questions and critically summarizing the overwhelming tide of recent research results, Apoptosis and Cancer Chemotherapy illuminates not only the potential targets for tumor therapy, but beyond that, potential control points for cancer and such diverse diseases as viral infection, neurodegenerative disorders, and stroke. This collection of cutting-edge reviews by established leaders in the field critically summarizes the recent discoveries concerning apoptosis, cell suicide. The book looks forward to the time when such cell death can be controlled to treat cancer and a host of other diseases as diverse as viral infection, neurodegenerative disorders, and stroke.
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p53 Apoptosis and Chemotherapy
The Role of p53 in Chemosensitivity
A Holistic Perspective
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Acad Sci USA antiapoptotic anticancer drugs apoptosis apoptosis induced B-cells Bcl-2 expression Bcl-2 family Bcl-2 family proteins Bcl-2 protein Bcl-XL binding Biol Chem breast cancer c-Abl Cancer Res 1996 carcinoma caspase activation caspase-3 caspase-8 caspases Cell Biol cell cycle cell lines cellular chemosensitivity chemotherapy cisplatin clinical colon colorectal correlated cytosol cytotoxic DNA damage domain downstream drug resistance effects endoplasmic reticulum etoposide fibroblasts GCTs gene genetic germ cell growth factor human hypoxia hypoxic increased induce apoptosis inhibition inhibitors interaction intestinal levels ligand lymphoma mechanism mediated membrane mice mitochondria molecular mutations Natl Acad Sci neuroblastoma NF-kB normal Oncogene ovarian cancer overexpression p53 function p53 mutations p53 protein p53 status p53-dependent paclitaxel patients phenotype phosphorylation proapoptotic Proc Natl Acad prognostic proliferation prostate cancer protease protein kinase radiation Reed JC regulation response role sensitivity studies target therapy tion tissues transcriptional treatment tumor cells tumor suppressor upregulation vitro vivo wild-type p53