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accumulation adipose tissue adrenal adult advancing age age changes aging process Amer amount Anat anatomical appearance areas arteries atrophy basophilic blood vessels body bone cartilage cent changes with age collagen colloid connective tissue cortex cortical cytoplasm days of age decade decrease in number degeneration degenerative changes dermis described diameter elastic elastin endoplasmic reticulum epidermis epithelium fatty female fibers fibrosis fibrous fish follicles ganglion Geront glomeruli granules growth hematoxylin histological hypertrophy increase individual infiltration kidney layers lipofuscin liver longevity lymph lymphocytes lymphoid tissue macronucleus male membrane mice mitochondria mouse nerve cells Nissl nodes nodules normal nuclear nuclei nucleolus occur old age older organs parenchyma parotid pigment pituitary Purkinje cells reticular rotifers seems seen senescence senile animals senile rats skin smooth muscle species specimens spleen stain structure submandibular glands thickening thymus thyroid tonsils tubules undergo vacuoles vertebrates weight Wistar Institute young Zool