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Melanocytes and Their Tumors
Malignant Tumors Melanomas and Related Lesions
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acquired nevi acral and/or areas associated atypia atypical benign biopsy blue nevi Cancer cell nevus cell type cellular blue nevus characteristic Clinical Features collagen compound nevus cutaneous cytologic atypia cytoplasm dendritic dermal component dermal nevus Dermatol desmoplastic melanoma Differential Diagnosis dysplastic nevi eosinophilic epidermis epithelioid cells excision fascicles Figure focal giant congenital nevi growth phase melanoma halo nevus higher magnification histologic infiltrate intraepidermal invasion junctional keratinocytes lentiginous lentigo maligna melanoma lesional cells lymphocytes malignant melanoma maturation melanin melanin pigment melanocytic nevi melanoma cells metastases Microscopic Features mitoses mitotic rate necrosis neoplasm nests nevus cells nodular melanoma noma nuclear pagetoid spread papillary dermis Pathol Pathology patients pattern percent pigment pigmented spindle cell present primary prognostic radial growth phase regression rete ridges reticular dermis risk scanning magnification seen sions skin spindle and epithelioid spindle cells Spitz nevi stains superficial spreading melanoma thickness tion tumor tumorigenic ulceration usually variant vertical growth phase