The Role of Potassium Channels in Sirolimus-induced Vascular Effects on Human Arteries

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ProQuest, 2008 - 160 pages
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Our third objective was to show that sirolimus causes an increase in the outward potassium current via the direct activation of the KATP. Our findings indicate that specific KATP currents were recorded from the human coronary artery smooth muscle cells and provide direct evidence that sirolimus causes an opening of the KATP channels in these cells. The data generated demonstrate the important role played by sirolimus on KATP channels in maintaining the vasomotor tone of human radial arteries and human coronary arteries. This study has important clinical applications as sirolimus-eluting stents are used to maintain patency of vessel grafts post coronary artery bypass surgery. Our findings may aid in developing and designing a more effective drug-eluting stent.
  

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Contents

CHARACTERIZATION OF THE RESPONSES
20
SIROLIMUS INDUCES ENDOTHELIUM
34
IMMUNOLOCALIZATION OF KATp CHANNEL
67
STUDY OF THE EFFECT OF SIROLIMUS ON
91
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