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Tumour Biology in Relation to Chemotherapy
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6-mercaptopurine Actinomycin acute administration adriamycin albumin alkylating agents allopurinol Alopecia analogues anti-cancer drugs anti-tumour activity anti-tumour effects antibiotics antimetabolite asparaginase Bleomycin bone marrow Bone marrow depression breast cancer cancer cells cancer chemotherapy carcinoma cause cell cycle central compartment chemo chemotherapeutic agents chlorambucil Classification clinical trials compounds concentration cyclophosphamide cytotoxic drugs daunorubicin Dilution Supplied disease Dosage dose drug treatment enzyme excreted factors Figure fluid fluorouracil folinic acid function gastrointestinal growth fraction half-life hexamethylmelamine hormone immune response immunotherapy increased inhibitors inhibits interactions intrathecal kinetic leukaemia liver lung lymphocytes Lymphoma malignant mechanism of action melphalan membrane metabolism metabolites methotrexate methotrexate treatment mg vials Mithramycin molecule monophosphate Mucositis Nausea and vomiting neoplasms normal tissues nucleic acid nucleotides oral Pharmacology phase plasma Procarbazine protein purine pyrimidine radiotherapy receptors Reconstituted reductase renal ribonucleotide schedule serum side-effects specific stable stem cells steroid therapeutic therapy thymidine toxic effects tumour tumour cells urine vinblastine vincristine