Chronic cardiac disease: optimizing therapeutic efficacy in heart failure
Diseases affectIng the heart represent a major and costly burden to both society and to the individual. In this context, both intermediate coronary syndrome and chronic congestive heart failure are associated with unacceptably high levels of morbidity and mortality; especially among certain "high-risk" individuals. The studies described in this book were designed to identify and address (through the application of relatively novel and potentially useful adjunctive therapeutic strategies) some of the determinants of suboptimal therapeutic repsonse in both these conditions.
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ACE inhibitors acute myocardial infarction analysis and/or Arch Intern associated atrial fibrillation Australian baseline beneficial effects cancer captopril cardiac Charlson Index chronic congestive heart chronic heart failure chronically ill clinical trials Co-morbidity cohort Coll Cardiol compliance component congestive heart failure coronary artery disease correlates costs diagnosis of heart digoxin ejection fraction enalapril Engl event-free survival example function HBI group HBI patients healthcare heart disease home visit home-based intervention hospital admissions hospital discharge hospitalization for heart improved increased index admission ischaemic Lancet left ventricular ejection left ventricular systolic lisinopril losartan management of heart Metoprolol morbidity mortality odds ratio older out-of-hospital deaths overall patients with chronic patients with heart pharmacological population post-hoc analysis potential prescribed medications primary end-point principal diagnosis randomized reduced regimen risk score Scotland Scottish six months spironolactone Stewart study follow-up study intervention survival rates therapeutic treatment UC patients unplanned hospitalization unplanned readmissions ventricular systolic dysfunction women