Drugs of AbuseLeslie Iversen Underlying the design of the Handbook of Psychopharmacology is a prejudice that the study of drug influences on the mind has advanced to a stage where basic research and clinical application truly mesh. These later volumes of the Handbook are structured according to this conception. In certain volumes, groups of drugs are treated as classes with chapters ranging from basic chemistry to clinical application. Other volumes are assembled around topic areas such as anxiety or affective disorders. Thus, besides chapters on individual drug classes, we have included essays addressing broad areas such as "The Limbic-Hypothalamic-Pituitary-Adrenal System and Human Be havior" and "Peptides and the Central Nervous System. " Surveying these diverse contributions, one comes away with a sentiment that, far from being an "applied" science borrowing from fundamental brain chemistry and physiology, psychopharmacology has instead provided basic researchers with the tools and conceptual approaches which now are advancing neurobiology to a central role in modern biology. Especially gratifying is the sense that, while contributing to an understanding of how the brain functions, psychopharmacology is a discipline whose fruits offer genuine help to the mentally ill with promises of escalating benefits in the future. L. L. 1. S. D. I. S. H. S. VII CONTENTS CHAPTER 1 Drug Self-Administration: An Analysis of the Reinforcing Effects of Drugs Roy PICKENS, RICHARD A. MEISCH, and TRAVIS THOMPSON 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I 2. Methods of Self-Administration . . . . . . . . . . . . . . . . . . . . . . . 3 3. Establishing Drugs as Reinforcers. . . . . . . . . . . . . . . . . . . . . . 4 4. Characteristics of Self-Administration . . . . . . . . . . . . . . . . . . 7 4. 1. Ethanol. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
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A-THC abstinence syndrome abuse acetylcholine action acute agonist-antagonists agonists alcohol addicts analgesia analgesic analgesic activity anesthetic anxiety barbiturates behavior benzomorphan biological blood alcohol levels brain cannabinoids cannabis changes Chem chronic clinical cocaine codeine compounds decreased depolarization depression DMHP drinkers drinking drug intake effects of alcohol effects of opiates ethanol excitatory experimental factors function GABA heroin hydroxyl increase inhibition injection dose interaction intravenous Jasinski marihuana Martin Mello Mendelson metabolism methadone mg/kg mice molecule morphinans morphine motoneurons nalorphine naloxone narcotic antagonist neurons Nicoll nitrogen nociceptive nociceptive stimulus observed opiate opiate administration opiate agonists pain patients pentazocine pentobarbital pethidines Pharmacol pharmacological physical dependence Physiol physiological Pickens placebo potency potential presynaptic produce Psychiat Psychopharmacologia rats reaction receptor reflex reinforcement release reported respiratory response rhesus monkeys self-administration sleep slow-wave sleep spinal studies subjects substitution synaptic testosterone tetrahydrocannabinol Ther tion tolerance transmitter Wikler