Genetic Toxicology of Complex MixturesMichael D. Waters Contained in this volume are the proceedings of the international conference on the "Genetic Toxicology of Complex Mixtures," held from July 4-7, 1989, in Washington, DC. This meeting was a satellite of the "Fifth International Conference on Environmental Mutagens" and the seventh in a biennial series of conferences on "Short-term Bioassays in the Analysis of Complex Environmental Mixtures. " Our central objective in calling together key researchers from around the world was to extend our knowledge of the application of the methods of genetic toxicology and analytical chemistry in the evaluation of chemical mixtures as they exist in the environment. This conference emphasized the study of genotoxicants in air and water, and the assessment of human exposure and cancer risk. The latest strategies and methodologies for biomonitoring of genotoxicants (including transformation products) were described in the context of the ambient environment. Source character ization and source apportionment were discussed as an aid to understand ing the origin and relative contribution of various kinds of complex mix tures to the ambient environment. Similarly, investigations of genotoxi cants found in the indoor environment (sidestream cigarette smoke) and in drinking water (chlorohydroxyfuranones) were given special attention in terms of their potential health impacts. New molecular techniques were described to enable more precise quantitation of internal dose and dose to-target tissues. The emphasis of presentations on exposures/effects assessment was on integrated quantitative evaluation of human exposure and potential health effects. |
Contents
Development and Application of New Methodologies | 1 |
Identification of Genotoxic Agents in Complex Mixtures | 11 |
Human Exposure to Airborne Mutagens Indoors | 33 |
Copyright | |
25 other sections not shown
Other editions - View all
Common terms and phrases
4-aminobiphenyl acid adduct levels agents air pollution airborne particulate matter ambient air Ames test analysis animals antibodies aquatic bacterial benzo(a)pyrene bioassays biological biomarkers Carcinogenesis carcinogens carcinogens and mutagens chemical chlorine chromosomal aberrations cigarette smoke clastogenic combustion Complex Mixtures Edited compounds concentrations detected diesel DNA adducts DNA damage dose dose-response dose-response relationship drinking water ecotoxicological effects emissions environment environmental epidemiological evaluation exposed forward mutation fraction Genetic Toxicology genotoxic Health human exposure humic IARC identified indoor induction larvae liver lung cancer markers measured metabolic method mice micronucleated micronuclei micronucleus test monitoring Muta mutagenic activity mutagenic response mutagenicity tests mutation assay nitroarenes organic extracts outdoor oxide ozone PAHs Plenum Pleurodeles polycyclic aromatic hydrocarbons potential present quantitative rats Research risk assessment S-9 mix Salmonella typhimurium samples sensitive short-term specific studies tissue toxicity Toxicology of Complex tumor vitro vivo Xuan Wei