Mechanisms of Angiogenesis

Front Cover
Matthias Clauss, Georg Breier
Springer Science & Business Media, Feb 24, 2005 - Medical - 307 pages
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The induction of blood vessel growth as part of an adaptive process can be either exaggerated, such as in tumors, or too slow, as in ischemic diseases of heart and brain. Therefore it is an interesting target for medical intervention. This volume presents a thorough reconsideration of our current knowledge of factors and principles involved in angiogenic processes. It proceeds from a "macroscopic " perspective through cellular and physical mechanisms to the molecular level . In the first part, angiogenesis in physiological as well as pathological processes is described with a focus on embryogenesis, the reproductive system and the growing heart. The second part deals with cellular and physical mechanisms leading to angiogenesis, and the  last part presents a deeper insight into molecular mechanisms of blood vessel growth, including knockout studies of essential angiogenic molecules, the identification of signaling steps in angiogenesis and the importance of cellular junctions.
  

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Contents

How do endothelial cells orientate?
3
New insights into intussusceptive angiogenesis
17
Angiogenesis in the female reproductive system
35
Arterialization coronariogenesis and arteriogenesis
53
Sprouting angiogenesis versus cooption in tumor angiogenesis
65
role of angiotensin II
77
Can tumor angiogenesis be inhibited without resistance?
95
Cellular and physical mechanisms of blood vessel growth
113
Can angiogenesis be exercised?
155
Angiogenesis a selfadapting principle in hypoxia
163
Cellular mechanisms of arteriogenesis
181
Balancing luminal size and smooth muscle proliferation a key control point in atherosclerosis and arteriogenesis
193
Molecular mechanisms of angiogenesis
207
The role of VEGF in the regulation of physiological and pathological angiogenesis
209
The antiinflammatory actions of angiopoietin1
233
The hemostatic system in angiogenesis
247

Role of pericytes in vascular morphogenesis
115
Role of monocytes and macrophages in angiogenesis
127
Bone marrowderived endothelial progenitor cells for neovascular formation
147
Signal transduction in angiogenesis
267
Index
301
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