Mechanisms of Angiogenesis

Front Cover
Matthias Clauss, Georg Breier
Springer Science & Business Media, Feb 24, 2005 - Medical - 307 pages
0 Reviews
Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.
  

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

How do endothelial cells orientate?
3
New insights into intussusceptive angiogenesis
17
Angiogenesis in the female reproductive system
35
Arterialization coronariogenesis and arteriogenesis
53
Sprouting angiogenesis versus cooption in tumor angiogenesis
65
role of angiotensin II
77
Can tumor angiogenesis be inhibited without resistance?
95
Cellular and physical mechanisms of blood vessel growth
113
Can angiogenesis be exercised?
155
Angiogenesis a selfadapting principle in hypoxia
163
Cellular mechanisms of arteriogenesis
181
Balancing luminal size and smooth muscle proliferation a key control point in atherosclerosis and arteriogenesis
193
Molecular mechanisms of angiogenesis
207
The role of VEGF in the regulation of physiological and pathological angiogenesis
209
The antiinflammatory actions of angiopoietin1
233
The hemostatic system in angiogenesis
247

Role of pericytes in vascular morphogenesis
115
Role of monocytes and macrophages in angiogenesis
127
Bone marrowderived endothelial progenitor cells for neovascular formation
147
Signal transduction in angiogenesis
267
Index
301
Copyright

Common terms and phrases

Bibliographic information