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Contents
Common terms and phrasesactivity assays Basolateral bile binding bioavailability Biol cells cerivastatin clearance Clin Pharmacol Ther clinical coadministration compounds cyclosporine CYP enzymes CYP3A CYP450 enzymes cytochrome P450 DDIs digoxin dose drug discovery Drug Metab Dispos drug transporters drug-metabolizing enzymes drug–drug interactions effect efflux transporters evaluation fexofenadine gemfibrozil gene expression genetic genome grapefruit juice Greenblatt DJ hepatic hepatic uptake hepatocytes Houston JB human hepatocytes human liver microsomes inactivation increased incubation induction intestinal involved isoforms itraconazole ketoconazole kidney kinact kinetic mdr1a mechanism mechanism-based membrane metabolism metabolites mice microarray microsomes midazolam Moltke Mrp1 MRP2 multidrug Neuvonen PJ OATP1B1 Obach organic anion transporting P-glycoprotein P-gp P450 isoforms pathways Pharm pharmacokinetic Pharmacol Exp Ther Phenotyping plasma concentrations polymorphism potential pravastatin prediction probe substrates protein ramelteon rCYP reaction renal repaglinide rifampicin rifampin ritonavir role saquinavir studies substrate substrate concentration Sugiyama talinolol test article Venkatakrishnan vitro vitro data vivo Vmax Bibliographic information
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