Glial Cell Function

Front Cover
B. Castellano López, Bernardo Castellano, Manuel Nieto-Sampedro
Gulf Professional Publishing, 2003 - Medical - 757 pages
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Although knowledge of the development and differentiation of glial cells has significantly increased in recent years, there are still many questions unanswered. The first section of the book is devoted to this very active topic and includes contributions on Schwann cells, oligodendrocytes, astroglia and microglia.

The second section of the book covers cellular interactions, the role they play on myelination and remyelination, how these interactions take place and the molecules involved.



The third section of this volume focuses on the interactions of neurons with glial cells and their role in brain function. Neuron-glia cross talk appears to be fundamental for synaptic transmission and several chapters in this section address this topic.

The topic of how glial cells react to brain injury and how they participate in neuroprotection and brain repair is covered in section four of this book. As our knowledge about the molecules involved in the regenerative properties of glia increases, new avenues are open for the use of genetically modified glia with therapeutic purposes.



The final section of the book is devoted to therapeutic approaches to tumours, viral and prion infections. Gene therapy is a promising approach for the treatment of gliomas, one of the most devastating forms of cancer. A chapter on prion diseases and microglia addresses a question of tremendous actuality, since prion diseases in cows is at this moment the major veterinary problem in Europe and has created a considerable social alarm.

  

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Contents

Regulation of genes involved in Schwann cell development and differentiation
3
Regulation of radial glia phenotype
13
lessons from GFAP and vimentin knockout
23
a target for steroid hormones
31
Thyroid hormone role in nervous system morphogenesis
41
Early origin and colonization of the developing central nervous system
51
its development and role as a neuropathology sensor
61
the roles
81
Role of nuclear factor kappa B in neuropathological mechanisms
391
astrocytes show their sensitive side
405
Glial expression of heat shock proteins HSPs and oxygenregulated proteins
427
a role for glu
441
PEA15 as a dou
455
Astroglia play a key role in the neuroprotective actions of estrogen
469
Inflammation and cytokine signalling
479
Inhibition of nitric oxide production for downregulation of CNS inflammation
499

Astrocyte influences on oligodendrocyte progenitor migration
97
TenascinR as a regulator of CNS glial cell function
103
Process extension and myelin sheet formation in maturing oligodendrocytes
115
Recent advances in human perinatal white matter injury
131
Models for demyelination
149
The response of adult oligodendrocyte progenitors to demyelination in
165
Neural precursors and demyelinating diseases
175
What roles do growth factors play in CNS remyelination?
185
Molecular mechanisms of interactions between radial glia and neurons
197
Connexins and gap junctional communication in astrocytes are targets
203
Glial signalling in response to neuronal activity in the leech central nervous
215
Glial cells as active partners in synaptic functions
227
Calcium signaling in retinal glial cells and its effect on neuronal activity
241
physiological
255
lonotropic glutamate receptors in astrocytes
287
Metabotropic glutamate receptors in freshly isolated astrocytes from rat hip
301
The nitric oxidecyclic GMP system in astroglial cells
325
Glial diffusion barriers during aging and pathological states
339
Glial cell responses to lipids bound to albumin in serum and plasma
367
Chemokine targets in acute brain injury and disease
507
Microglial chemokines and chemokine receptors
525
The role of chemokines and chemokine receptors in CNS inflammation
533
Signals regulating neurotrophin expression in glial cells
545
Microglial signalling cascades in neurodegenerative disease
555
Transcription factors in nerve regeneration
569
The role of astrocytes in axonal regeneration in the mammalian
587
inhibitory components of the glial scar
611
Axon regeneration across the dorsal root entry zone
621
Transplants of olfactory bulb ensheathing cells promote functional repair
641
prospects
655
Immune escape of gliomas
685
Clinical trials of adenoviralmediated suicide gene therapy of malignant gliomas
699
from suicide to homicide
711
Glial cells as targets of viral infection in the human central nervous system
721
possible implications of microglial cells
737
Subject Index
751
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