The Newborn Brain: Neuroscience and Clinical ApplicationsHugo Lagercrantz, M. A. Hanson, Laura R. Ment, Donald M. Peebles Development of the brain and the emergence of the mind constitute some of the most important concerns of contemporary biology. Disturbances during fetal life may have profound implications for a child's future neurological and psychological development, which can in turn impact society. The new edition of this highly respected work presents a comprehensive review of the basic mechanisms of brain development and the pathophysiology of disorders of the infant brain, written by a team of distinguished neuroscientists, neonatologists, and neuropediatricians. The book follows the main milestones of brain development, from formation of the neural tube and wiring of the neurons in the brain. Neurotrophic factors, neurotransmitters, glial cell biology, cerebral circulation development of sensory functions are all described in detail. Furthermore, there are more philosophical chapters on the evolution of the brain and the emergence of consciousness. Clinical considerations are highlighted where relevant. |
Contents
| 2 | |
Historic box 1 | 36 |
Richard S Nowakowski | 161 |
Neurotransmitters and neuromodulators 99 Mary A Rutherford | 211 |
Followup | 227 |
Clinical aspects and disease 345 Mijna HaddersAlgra and Hans Forssberg | 245 |
Hypoxicischemic encephalopathy | 261 |
Clinical assessment and therapeutic 23 On the emergence of consciousness 377 | 281 |
Clinical aspects of brain injury in | 301 |
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abnormal acid activity adult aEEG afferent apoptosis asphyxia associated astrocytes auditory axons BDNF birth brain development brain injury Brain Research caspase cell death cerebral cortex Changeux clinical cognitive cortical cytokines damage Developmental differentiation dorsal early effects embryonic encephalopathy expression fetal fetus fibers findings first function GABA gene genetic gestation glial glutamate hemorrhage human brain hypothermia hypoxia hypoxia-ischemia hypoxic-ischemic identified imaging immature increase infection inflammatory influence inner ear ischemia Journal of Neuroscience layer lissencephaly maturation mechanisms ment metabolism mice molecular molecules mouse mutations neocortex neonatal nervous system neural tube Neurology neuronal migration neurons Neuroscience neurotransmitter neurotrophins newborn NMDA normal outcome pathways patterns Pediatric Research perinatal perinatal asphyxia periventricular plasticity postnatal prenatal preterm infants protein Rakic receptors refinement regulation response role Schousboe Science seizures sensory Shatz signaling significant somatosensory specific spinal cord stimulation studies subplate synapses synaptogenesis syndrome tion transcription TrkB visual cortex weeks white matter