Coffee: PhysiologyR.J. Clarke, R. Macrae |
Contents
Physiologically Active Substances in Coffee | 1 |
2 COFFEE CONSTITUENTS | 2 |
22 Chlorogenic Acids and Related Substances | 3 |
23 Glycosides | 8 |
24 Lipids | 9 |
25 Trigonelline and Niacin | 13 |
26 Volatile Substances | 14 |
27 Minerals and Related Substances | 16 |
52 Environment for Sensory Assessment | 166 |
54 Panels vs Expert Judgement | 168 |
Animal Feeding Studies with Coffee | 171 |
2 CHRONIC TOXICITY AND CARCINOGENICITY | 172 |
22 Studies on Rats | 173 |
23 Studies on Mice | 179 |
24 Caffeine Coffee and Tumour Promotion and Inhibition | 181 |
25 Caffeine Studies | 182 |
28 Partially Identified Constituents | 17 |
32 Pesticides | 19 |
4 SUMMARY AND CONCLUSIONS | 24 |
REFERENCES | 25 |
The Metabolism of Coffee Constituents | 33 |
2 MINERALS | 34 |
33 Phytate | 35 |
52 Waxes | 36 |
54 Terpenes | 37 |
55 Kahweol Cafestol and Diterpene Glycosides | 39 |
6 ALIPHATIC COMPOUNDS | 40 |
72 Chlorogenic Acids | 41 |
73 Eugenol | 43 |
74 Guaiacol | 44 |
8 HETEROCYCLIC COMPOUNDS | 45 |
84 Mailtard Reaction Products | 46 |
86 Other Heterocyclic Compounds | 47 |
92 Caffeine | 50 |
10 CONCLUSIONS | 51 |
REFERENCES | 52 |
Epidemiological Studies on the Effects of Coffee Drinking | 57 |
2 STUDY OF COFFEE CONSUMPTION AND MORTALITY RATES AMONG 10000 HYPERTENSIVES | 59 |
23 Results | 61 |
24 Discussion | 62 |
3 COFFEE CONSUMPTION AND FIBROCYSTIC BREAST DISEASED | 63 |
32 Patients and Methods | 64 |
33 Results | 65 |
34 Discussion | 67 |
35 Review of Literature | 68 |
36 Summary and Acknowledgement | 70 |
4 HABITUAL COFFEE CONSUMPTION AND CHOLESTEROL LEVELS | 71 |
43 Discussion | 76 |
44 Summary of Findings | 77 |
Physiological Effects of Coffee and its Components | 81 |
22 Behavioural Effects | 82 |
23 Biochemical Effects | 89 |
24 Central Respiratory Effects | 93 |
3 CARDIOVASCULAR SYSTEM | 94 |
32 Studies on Animals | 96 |
33 Studies in Man | 104 |
4 COFFEE AND THE GASTROINTESTINAL TRACT | 107 |
42 Effects of Coffee | 109 |
43 Conclusions | 114 |
REFERENCES | 116 |
Nutritional Factors | 125 |
The Physiology of Flavour Taste and Aroma Perception | 141 |
12 Sensory Perceptions that Influence Flavour | 142 |
13 Sensory Stimuli Associated with Odour and Taste | 143 |
PHYSIOLOGICAL MECHANISMS OF THE TONGUE | 144 |
22 Taste Perception | 147 |
23 Theories of Taste Perception | 148 |
24 Molecular Structure and Taste | 149 |
25 Taste Interrelationships | 153 |
32 Odour Perception | 156 |
33 Molecular Structure and Odour | 159 |
4 COFFEE FLAVOUR | 161 |
42 Basic Flavour of Coffee Brews | 162 |
43 Other Variants of Coffee Flavour | 164 |
5 APPLICATIONS TO SENSORY ANALYSIS OF COFFEE | 165 |
26 Conclusions | 183 |
3 TERATOLOGY AND REPRODUCTION | 185 |
33 Studies on Mice | 188 |
34 Caffeine Studies | 189 |
35 Conclusions | 191 |
REFERENCES | 192 |
Mutagenicity of Coffee | 195 |
21 Bacterial Tests | 196 |
22 Mammalian Tests in vitro | 199 |
23 Tests under in vivo Conditions | 202 |
24 Mammalian Tests in vivo | 204 |
3 MUTAGENICITY EVALUATION OF COFFEE COMPONENTS | 205 |
31 Aliphatic Carbonyls | 206 |
32 Methylxanthines | 207 |
34 Hydrogen Peroxide | 208 |
41 Interactions between Coffee Constituents | 209 |
5 RISK ASSESSMENT | 210 |
6 SUMMARY | 211 |
Allergens and Mould Toxin Contaminants | 215 |
12 Importance of Fungi | 217 |
13 Growth of Fungi | 220 |
14 Fungalbased Diseases and Disorders | 228 |
15 Immunology | 243 |
2 ALLERGENS | 267 |
22 Microscopic Analysis of Green Coffee Bean Factory Dust | 272 |
23 Chemical Analysis of Green Bean Coffee Dust | 274 |
24 Case and Clinical Studies on Coffee Workers Handling Green and Roasted Coffee | 276 |
25 Other Occupational Pulmonary Diseases | 287 |
3 MYCOTOXINS FOUND IN COFFEE BEANS | 290 |
31 Mould and Other Microbial Growth on Coffee Beans at Elevated Relative Humidities | 291 |
32 Ochratoxin in Mouldcontaminated Coffee Beans | 292 |
33 Mycotoxin Production in Nondecaffeinated and Decaffeinated Green Coffee Beans | 293 |
34 Sterigmatocystin in Coffee Beans | 298 |
35 Fate of Mycotoxins during Roasting | 301 |
36 Incidence of Moulds in Coffee Beans Surface and Subsurface Populations | 302 |
37 Mould and Other Microbial Growth Potential on Coffee Beans from Production Site to Roaster | 304 |
38 Storage and Transport of Coffee Beans Storage at Production Site | 307 |
39 Sea Transport of Green Coffee Beans | 308 |
4 CONCLUSIONS | 310 |
REFERENCES | 313 |
Polycyclic Aromatic Hydrocarbon Contaminants in Coffee | 321 |
12 Early History of Cancer | 322 |
13 Discovery of 34Benzpyrene | 324 |
14 Physical Viral and Chemical Carcinogens | 326 |
15 Carcinogenic Activity and Structure of Polynuclear Aromatic Carcinogens | 329 |
16 Carcinogenic Activity and Metabolism | 332 |
17 Twostage Theory and Quantitation of Carcinogenesis | 334 |
18 Enzymatic Transformation of Polynuclear Aromatic Hydrocarbons into Carcinogens | 338 |
19 Detoxification and Nucleic Acid Repair and Inhibition | 343 |
110 Carcinogenic Polynuclear Hydrocarbons Present in the Human Environment | 346 |
112 Carcinogenic Constituents of Coal Tar Industrial Automotive and Residential Effluents and Tobacco Smoke | 348 |
2 BENZOaPYRENE CONTENT OF COFFEE PRODUCTS AND BYPRODUCTS | 351 |
3 CONCLUSIONS | 358 |
REFERENCES | 360 |
Glossary of Some Terms and Abbreviations Used | 365 |
Etymology of Some PhysiologyMedical Terms | 373 |
377 | |
Common terms and phrases
3,4-benzpyrene activity adenosine aflatoxin allergens allergy animals antibodies antigen arabica aromatic ASIC Aspergillus bacterial benzo[a]pyrene beverage blood breast cafestol caffeic acid caffeine cancer carcinogenic catecholamines caused Chem chlorogenic acids cholesterol Clin coffee bean dust coffee brew coffee consumption coffee drinkers coffee dust coffee workers components compounds concentration containing decaffeinated decaffeinated coffee diet disease dose drinking effects of caffeine effects of coffee enzymes extraction factors flavour Food fungi green bean green coffee beans growth human hydrocarbons hypersensitivity immunoglobulins increase ingestion inhibition instant coffee interaction kahweol liver lymphocytes mast cells metabolic metabolites methylxanthines mould mutagenic Mutat mycotoxins nerve Nutr observed ochratoxin odour Pharmacol physiological plasma present Proc production protein R₁ rats reactions reactive receptors reported response roasted coffee secondary metabolites sensory serum specific sterigmatocystin studies substances symptoms taste theophylline tissue toxins trigonelline tumour vitro