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Mammalian SAdenosylmethionine Decarboxylase
Regulation of SpermidineSpermine N1Acetyltransferase
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3T3 cells AdoMac AdoMet-DC amino acid antiproliferative antitumor antizyme Bergeron RJ BESpm Biol Chem c-myc Cancer Res carcinogenesis Casero RA cDNA cell growth cell lines cell types cellular chromatin chromatin structure cloning codon coli concentrations cytotoxicity decrease DFMO effects of polyamine effects of spermine enzyme eukaryotic factor function glutamate glycine human ifenprodil inactivation increase induced inhibition inhibitors initiation interactions intracellular polyamine involved Marton LJ mechanism modulate Molecular mouse mRNA mutations Natl Acad Sci neurons NMDA receptors NR2 subunits NR2A nuclear nucleosomal ODC activity ODC gene ornithine decarboxylase Pegg AE polyamine analogs polyamine depletion polyamine metabolism polyamine pathway Porter CW potential Proc Natl Acad proenzyme putrescine region regulation residues response ribosome role S-adenosylmethionine S-adenosylmethionine decarboxylase SAMDC SAMDC activity SAMDC mRNA sequence specific spermidine spermine synthase SSAT SSAT activity SSAT gene stimulation studies substrate synaptic target tion tissue transcription translation tumor cells uORF vitro vivo