Kuby Immunology

Front Cover
Macmillan, 2007 - Medical - 574 pages
9 Reviews
The only textbook written for undergraduates by teachers of the course, this bestseller presents the most current concepts in an experimental context, conveying the excitement of scientific discovery, and highlighting important advances while providing unsurpassed pedagogical support for the first-time learner.  The new edition is thoroughly updated, including most notably the new chapter on innate immunity.
  

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great book about immunology

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Contents

PARTI Introduction
1
Infection and Immunity
7
AntigenPresenting Cells Interact with T Cells
14
CLINICAL FOCUS ALLERGIES AND ASTHMA
20
Natural Killer Cells
24
Hematopoietic Homeostasis Involves Many Factors
26
5
34
12
40
Chagass Disease Is Caused by a Parasite
320
HEVLike Structures Appear
346
NK Cells and T Cells Share Some Features
361
IgEMediated Type I Hypersensitivity
372
Several Pharmacologic Agents Mediate
379
Several Clinical Methods Are Used
386
Reactions Can Be Localized
392
The Immune System in Health and Disease
401

16
49
Connections between Innate and Adaptive Immunity
55
Proteins of the Acute Phase Response Contribute
61
NK Cells Are an Important First Line of Defense
68
Generation of BCell and TCell Responses
76
Basic Structure of Antibodies
84
Organization and Expression
111
VariableRegion Gene Rearrangements
116
Recombination Signal Sequences Direct Antibody Avidity Incorporates Affinity
148
Somatic Hypermutation Adds Diversity Bacterial Agglutination Is Used to Diagnose
154
Immunofluorescence
160
IgCene Expression Is Inhibited in T Cells 135 The Complement System
168
The Three Complement Pathways Converge MHC and Immune Responsiveness 206
175
Biological Consequences
208
Allelic Forms of MHC Genes Are Inherited by Displacing CLIP
215
The Exonlntron Arrangement of Class I and II TCell Receptor
223
Cellular Expression of MHC Molecules 203 TCR VariableRegion Genes Rearrange
229
Rearranged TCR Genes Are Assembled from
231
Affinity of TCR for PeptideMHC Complexes
238
TCell Maturation Activation
245
Some Central Issues in Thymic Selection
251
How Many TCR Complexes Must Be Engaged
258
Cell Death and TCell Populations
264
Differentiation
271
SelfReactive B Cells May Be Rescued by Editing
278
T Helper Cells Play a Critical Role in
290
Memory B Cells and Plasma Cells Are Generated
296
Immune Effector Mechanisms
302
Cytokine Receptors Fall within Five Families
308
Cytokine Antagonists
314
Antigen Sequestration Is a Means
407
Autoimmunity Can Be Induced Experimentally
413
CLINICAL FOCUS WHY ARE WOMEN MORE Clinical Transplantation 440
416
Transplantation Immunology 425 Viral Infections
448
Similar Antigenic Profiles Foster The Humoral Response to Influenza Is Strain Specific
454
CLINICAL FOCUS Is THERE A CLINICAL FUTURE Parasitic Diseases
460
Privileged Sites Accept Antigenic Mismatches 439 Innate Immunity Controls Most Fungal Infections
466
Emerging Infectious Diseases 467 AIDS and Other Acquired or Secondary
467
CLINICAL FOCUS THE THREAT OF INFECTION HIVAIDS Has Claimed Millions of Lives Worldwide
505
CHALLENGES IN THE HIV1 Infection Leads to Opportunistic Infections
512
Passive Immunization Involves Transfer
518
Designing Vaccines for Active Immunization 481
525
Use of Synthetic Peptides as Vaccines Tumor Antigens
531
Recombinant Vector Vaccines 488
538
XRay Crystallography Provides
553
Southern Blotting Detects DNA of a Given Sequence
559
KnockIn Technology Allows the Replacement
565
Advances in Fluorescent Technology
571
CD Antigens
1
CD Antigens
3
Cytokines A27
27
Cytokines A27
29
Glossary
37
Answers to Study Questions AN1
57
Answers AN1
1
336
4
Leukocyte Activation
13
331
21
Copyright

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About the author (2007)

Thomas J. Kindt, National Institutes of Health, is the Director of the Intramural Research Program at the National Institute of Allergy and Infectious Disease, which places him in daily contact with the cutting edge of experimental and clinical immunology. As head of the Immunogenetics Research Section, Tom's research interests include the study of retroviral infections in animal models.

Richard A. Goldsby, Amherst College, is a member of the department of Biology at Amherst College. His research interests include the somatic mutation of antibody genes in the generation of antibody diversity. Since the 1980s, he has served as a Course Director in the National Science Foundation-Chatauqua Short Course Program for the education of college teachers, annually presenting a course on current advances in immunology.

Barbara A. Osborne, University of Massachusetts at Amherst, is a recognized contributor to the fast-moving area of apoptosis, or programmed cell death. A highly active researcher, Barbara also teaches immunology to undergraduate and graduate students.

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