Viruses and Human DiseaseThis is the first text to examine the connection between virology and human disease. It is also the first book to integrate basic virology with pathophysiological conditions. By contrast, most virology textbooks focus on the molecular biology involved without adequate reference to physiology. Viruses and Human Disease is four-color throughout and contains clearly labeled figures and tables. Key Features*Provides a concise overview of animal viruses, emphasizing those causing diseases in humans;* Integrates discussion of molecular biology, epidemiology, and the history of human viruses;* Presents treatment of prions, gene therapy, and vaccine development;* Illustrated in color by an expert virologist;* Includes world maps depicting the current distribution of existing and newly emerging viruses |
Contents
1 | |
33 | |
Chapter 3 PlusStrand RNA and DoubleStrand RNA Viruses | 57 |
Chapter 4 MinusStrand RNA Viruses | 123 |
Chapter 5 Viruses Whose Life Cycle Uses Reverse Transcriptase | 171 |
Chapter 6 DNAContaining Viruses | 221 |
Chapter 7 Subviral Agents | 279 |
Chapter 8 Host Defenses against Viral Infection and Viral Counterdefenses | 303 |
Chapter 9 Gene Therapy | 347 |
367 | |
373 | |
375 | |
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Common terms and phrases
activity Adapted adenovirus alphaviruses animals antibodies antigen antigenomic apoptosis Arenaviridae binding budding capsid capsid protein caspases cause cellular cleavage cleaved codon complex contain CTLs cycle cytokines cytoplasm developed disease DNA replication domains encephalitis encode envelope enzyme epidemic expression FIGURE Flaviviridae function gene genera genome genome organization genomic RNA genus glycoproteins hepatitis herpesviruses host human icosahedral illustrated in Fig immune response immune system induce infected cells influenza interactions isolated measles membrane mice molecules monkeys mRNA nucleocapsid nucleotides nucleus occurs oncogene particles pathogens pathway peptide poliovirus polyprotein population poxviruses present prion produced protease PrPSc rabies receptor region respiratory retroviruses RNA polymerase RNA viruses RNase H segments sequence shown in Fig spliced strand structural proteins subgenomic surface synthesis T-cell Table tion transcription translated transmission tumor vaccine vaccinia vectors Vertebrates viral genome viral infection viral RNA virion virus Worldwide
Popular passages
Page 368 - SC (1995). The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution. Nature 375:291—298.
Page 30 - G. (1998) The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells. J Virol.
Page 31 - CL, and et al. (1994). Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein. Cell 77, 761-771. Minskaia, E., Hertzig, T., Gorbalenya, AE, Campanacci, V., Cambillau, C., Canard, B., and Ziebuhr, J. (2006). Discovery of an RNA virus 3'— >5' exoribonuclease that is critically involved in coronavirus RNA synthesis.
Page 4 - discoveries concerning the interaction between tumor viruses and the genetic material of the cell.