Professional Communications, Jan 1, 2004 - Medical - 400 pages
Clinical application of antithrombotic therapy in both arterial disease (acute coronary syndromes, acute MI, peripheral arterial disease, valvular heart disease, atrial fibrillation) and venous disease (venous thromboembolic disease and pulmonary embolism). Results of major clinical trials and their implications for clinical practice are reviewed.
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Abbreviations abciximab acute coronary syndrome acute myocardial infarction administration angioplasty Ann Intern antibodies anticoagulant therapy antiphospholipid antiplatelet therapy antithrombotic therapy aPTT aspirin atrial fibrillation benefit bivalirudin bleeding blood bolus bypass Circulation clinical trials clopidogrel clotting coagulation Coll Cardiol coronary artery death dose drug effect embolism Engl enoxaparin eptifibatide factor V Leiden fibrinogen fibrinolytic fibrinolytic therapy Figure fondaparinux glycoprotein GPIIb/IIIa heart valve hemorrhage heparin high-risk Ilb/IIIa increased Investigators ischemia ischemic Lancet LMWH mg bid mg daily molecular weight heparin mutation nonfatal occlusion oral anticoagulant percutaneous coronary intervention placebo plasma plasminogen activator platelet activation platelet aggregation platelet function platelet glycoprotein platelet inhibition prevention protein prothrombin randomised randomized trial recurrent reduced reteplase revascularization risk factors stenting stroke surgery Table Thromb Haemost Thrombolysis thrombophilia thrombotic ticlopidine tients TIMI tion tirofiban tissue treatment unfractionated heparin unstable angina vascular disease venous thromboembolism venous thrombosis warfarin ximelagatran