The Neutral Theory of Molecular Evolution

Front Cover
Cambridge University Press, 1984 - Science - 367 pages
4 Reviews
Motoo Kimura, as founder of the neutral theory, is uniquely placed to write this book. He first proposed the theory in 1968 to explain the unexpectedly high rate of evolutionary change and very large amount of intraspecific variability at the molecular level that had been uncovered by new techniques in molecular biology. The theory - which asserts that the great majority of evolutionary changes at the molecular level are caused not by Darwinian selection but by random drift of selectively neutral mutants - has caused controversy ever since. This book is the first comprehensive treatment of this subject and the author synthesises a wealth of material - ranging from a historical perspective, through recent molecular discoveries, to sophisticated mathematical arguments - all presented in a most lucid manner.
  

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User Review  - amarcobio - LibraryThing

I may be biased but I think this is an essential book to understand evolution. It is true that some pieces may be a bit out of date, the the whole book is still scientifically sound. The text is clear ... Read full review

Contents

From Lamarck o population genetics I
15
The neutral mutationrandom drift hypothesis as an evolutionary
34
Molecular evolutionary rates contrasted with phenotypic evolu
55
Some features of molecular evolution
98
Definition types and action of natural selection
117
Molecular structure selective constraint and the rate of evolution
149
Population genetics at the molecular level
194
Maintenance of genetic variability at the molecular level
253
Summary and conclusion
305
Copyright

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Page 342 - Gilbert, W. (1977) A new method for sequencing DNA. Proc. Natl. Acad. Sci. USA 74, 560-564.
Page 330 - Cordell, B., Bell, G. Tischer, E., DeNoto, FM, Ullrich, A., Pictet, R., Rutter, WJ & Goodman, HM (1979).
Page 347 - Dennis. 1979. Nucleotide sequence of the ribosomal protein gene cluster adjacent to the gene for RNA polymerase subunit ft in Escherichia coli.

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