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NmethylDaspartic acid NMDA receptor antagonist MK801
A parametric analysis of swim stressinduced analgesia in mice
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3-min swim agonist analgesia displayed analgesia induced analgesic response analysis antagonism autoradiography autotomy backcross baseline latency behavioral Belknap binding Brain Res bred for high breeding circuitry core body temperature correlated CXBK mice demonstrated Experiment experimental F2 hybrids footshock genes genetic determinants genetic drift genetic line HA/LA mice high and low homoscedasticity hot plate hot-plate test hypothermia inbred strains laboratory levorphanol Liebeskind line difference locus maximum possible effect mechanisms mice display mice selectively bred Mogil MOR analgesia morphine analgesia mouse naloxone naltrexone neurochemical NMDA NMDA receptor antagonist nociceptive opiate receptors opioid analgesia opioid and non-opioid opioid peptides paradigms parameters periaqueductal gray phenotypes polygenic post-swim rats recombinant inbred saline saline-treated selectively bred selectively bred mice significant line significant main effects SSIA magnitudes stressor swim duration swim in 20°C swim stress swim stress-induced analgesia swims produce Swiss-Webster mice thalamic two-way ANOVA U-50 analgesia water temperature