Bile acids and cholestasis: (XV International Bile Acid Meeting) : proceedings of the Falk Symposium 108 (Part 1 of the Gastrointestinal Week Titisee 1998) held in Titisee, Germany, October 12-13, 1998
Since the last International Bile Acid Meeting in Freiburg in 1996, considerable progress has been made in several areas of bile acid research. The different pathways of bile acid synthesis and their regulation have been further characterized. The molecular mechanisms for biliary secretion of bile acids have been elucidated and genetic defects of bile acid transport have been defined. Injurious as well as protective effects of different bile acids on the liver have been further studied. Finally, the beneficial effects of ursodeoxycholic acid in cholestatic liver diseases have been substantiated and the potential mechanisms of action have been explored. This book, the proceedings of the Falk Symposium No. 108 (XV International Bile Acid Meeting), held in Titisee, Germany, October 12-13, 1998, is dedicated to both basic and clinical aspects of bile acid research with a focus on bile acids and cholestasis.
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The regulation of different bile acid biosynthetic pathways
Transcriptional regulation of the cholesterol
Substrate specificity of NaVbile acid cotransporters
22 other sections not shown
activity apoptosis ASBT ATP-dependent basolateral bile acid synthesis bile acid transport bile duct bile salt bile salt export bile salt transport binding Biochem Biol Chem biopsy BSEP C7aH canalicular canalicular membrane cells chenodeoxycholic acid cholate cholestasis cholestatic cholestatic liver disease cholesterol cholesterol 7a-hydroxylase cholic acid Clin Invest clinical cloning concentrations CYP7A down-regulation excretion expression Falk Symposium familial intrahepatic cholestasis fibrosis Figure function Gastroenterology Hagenbuch hepatic hepatocellular hepatocytes Hepatol Hepatology human hydrophobic bile ileal bile acid imol/L intestinal isolated kinase lipid Lipid Res mdr2 Meier PJ metabolism mice molecular mRNA mRNA levels MRP2 mutations NaVbile acid cotransporter Ntcp organic anion transporter oxysterol P-glycoprotein pathway patients PFIC photoaffinity labelling Physiol primary biliary cirrhosis progressive familial intrahepatic protein rat hepatocytes rat liver receptor regulation secretion sequence sodium-dependent bile acid sodium/bile acid cotransporter Spgp sterol sterol 12a-hydroxylase studies substrate taurocholate therapy transport system treatment TUDCA UDCA uptake ursodeoxycholic acid y-GT