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The effect of mechanical stretch on insulin-like growth factor-I secretion by cardiac fibroblasts

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University of California, San Diego, 2006 - 108 pages

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Contents

MATERIALS AND METHODS
14
RESULTS
31
DISCUSSION
40

1 other sections not shown

Common terms and phrases

adult cardiac fibroblasts applied strain assayed for IGF-I autocrine/paracrine factors binding proteins cardiac myocytes cardiomyocytes Cardiovasc cell culture cellular chamber and indenter concentrations by ELISA conditioned media cyclic stretch device cytoskeleton endothelial cells equibiaxial exocytosis extracellular matrix factor-I fibroblasts were stretched Figure 12 focal adhesion G-proteins gene expression heart hypertrophy IGF-I concentrations IGF-I secretion IGFBP Insulin-like growth factor integrins MAPK mechanical forces mechanical stimuli mechanical stretch mechanotransduction membrane holder mitogen-activated protein kinases modulate myocardial infarction myocardium myostatin non-stretched cardiac fibroblasts normalized to total paracrine signaling Physiol pmol/lE6 cells presented as means proliferation rat cardiac fibroblasts receptor regulation release of IGF-I remodeling respond to mechanical Secretion by Cardiac secretion from cardiac secretion of IGF-I silicone membrane smooth muscle cells static stretch static stretch device stretch chamber stretch on IGF-I Stretch-activated ion channels stretch-induced IGF-I release Stretch-induced increases stretched cardiac fibroblasts total cell number tyrosine kinases ventricular verapamil vimentin

Bibliographic information

QR code for The effect of mechanical stretch on insulin-like growth factor-I secretion by cardiac fibroblasts
TitleThe effect of mechanical stretch on insulin-like growth factor-I secretion by cardiac fibroblasts
AuthorBetty S. Hu
PublisherUniversity of California, San Diego, 2006
Original fromthe University of California
DigitizedFeb 26, 2011
Length108 pages
  
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