Analysis of Human Genetic Linkage

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JHU Press, Mar 17, 1999 - Medical - 382 pages
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The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites. Each chapter ends with a set of problems, whose solutions are found at the end of the book.

New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of nonparametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits. Although the book's primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.

  

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Contents

Introduction and Basic Genetic Principles
1
Genetic Loci and Genetic Polymorphisms
24
Aspects of Statistical Inference
37
Basics of Linkage Analysis
53
The Informativeness of Family Data
84
Multipoint Linkage Analysis
114
Penetrance
151
Quantitative Phenotypes
171
Inconsistencies
236
Linkage Analysis with Mendelian Disease Loci
253
Nonparametric Methods
272
TwoLocus Inheritance
297
Complex Traits
306
Solutions to Study Problems
331
References
345
Index
377

Numerical and Computerized Methods
179
Variability of the Recombination Fraction
211

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About the author (1999)

Jurg Ott is a professor and head of the Laboratory of Statistical Genetics at Rockefeller University. He is editor-in-chief of Human Heredity and the author of the first generally available computer program on human linkage analysis (LIPED).

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