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11-desoxycortisol 11/3-hydroxylation acid Acta ACTH secretion action Addison's disease adenomas administration adrenal cortex adrenal gland adrenal insufficiency adrenal tumors adrenalectomy adrenocortical aldosterone aldosterone secretion amount androgens androstenedione angiotensin associated binding Biochem Biol biologic activity blood carcinoma cells cent Chem cholesterol Clin clinical compounds concentration congenital adrenal hyperplasia cortical corticoid corticosteroids cortisol cortisol secretion creased Cushing's disease Cushing's syndrome cyclic AMP decrease dehydroepiandrosterone demonstrated desoxycorticosterone dexamethasone diagnosis diurnal dose ectopic effect elevated Endocrinol Endocrinology enzyme estrogen excretion glucocorticoid hirsutism hormone hyperaldosteronism hypertension increased inhibit inhibitors lipid liver measurement membrane Metab metabolism metyrapone mineralocorticoid Nelson Nelson's syndrome normal subjects patients with Cushing's peripheral phospholipid pituitary gland pituitary tumors plasma ACTH levels plasma aldosterone plasma cortisol levels plasma levels plasma renin potassium present produce protein radioimmunoassay receptors renal renin response result seen serum sodium steroid stimulation stress studies substance suppression synthesis terone testosterone therapy tion tissue urinary urine vitro