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abnormalities acid activity acute allergic allografts animals antibiotics antibody antigen-antibody complexes antigens associated bacteria blood bone marrow cancer cause cell function cell-mediated cell-mediated immune cellular cent chains chemotactic chronic circulation clinical complement components complement system cytotoxic defects deficiency delayed hypersensitivity donor drug effect endotoxin enzymes erythrocytes factor globulin glomerulonephritis graft granules hemolytic host immune response immunodeficiency immunoglobulin immunologic immunosuppressive important increased inflammatory ingestion inhibition intracellular involved kidney lesions leukocytes levamisole lymph nodes lymphocytes lymphoid cells lymphoid tissues macrophages malignant mast cells mechanisms mediators membrane molecule monocytes neutrophils normal occur opsonic organisms pathogens pathway patients phagocytic cells phagocytosis plasma cells platelets present produce protein reactions receptors rejection renal result role sensitivity serum skin spleen steroids stimulation studies suppressor T cells syndrome synthesis therapy thymic thymus tibody tigen tion transfusion transplantation treatment tumor usually vaccine vascular viral infections virus viruses vitro