Metabolomics: The Frontier of Systems Biology (Google eBook)
Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. In the post-genome era, metabolism has taken on new significance for biological scientists: metabolites are the chemical basis of phenotypes that are final expressions of genomic information. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. The authors have been directly involved in the development of all the subject areas, including capillary electrophoresis, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Breakthrough achievements and the future of metabolome studies are described, making this book a valuable source for researchers in metabolomics in diverse fields, such as plant, animal, cellular, microbial, pharmaceutical, medical, and genetic sciences.
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Application of Electrospray Ionization Mass Spectrometry for Metabolomics
HighPerformance Liquid Chromatography and Liquid Chromatography Mass Spectrometry Analyses of Metabolites in Microorganisms
Metabolome Profiling of Human Urine with Capillary Gas ChromatographyMass Spectrometry
Metabolic Profiling by FourierTransform Ion Cyclotron Resonance Mass Spectrometry FTICRMS and Electrospray Ionization Quadrupole TimeOfFl...
Metabolome Analysis by Capillary Electrophoresis
Metabolomics in Arabidopsis thaliana
Lipidomics Metabolic Analysis of Phospholipids
Chemical Diagnosis of Inborn Errors of Metabolism and Metabolome Analysis of Urine by Capillary Gas ChromatographyMass Spectrometry
Part IV Metabolome Informatics
Introduction to the ARM Database Database on Chemical Transformations in Metabolism for Tracing Pathways
The GenomeBased ECELL Modeling GEM System
Hybrid DynamicStatic Method for LargeScale Simulation of Metabolism and its Implementation to the ECELL System
Part V Metabolomics and Medical Sciences
HighPerformance Liquid Chromatography for Metabolomics HighEfficiency Separations Utilizing Monolithic Silica Columns
Part III Applications of Metabolome Analysis to Biosciences
Combined Analysis of Metabolome and Transcriptome Catabolism in Bacillus subtilis
aciduria adenine amino acids Anal Chem analytical anionic Arabidopsis atomic Bacillus subtilis biochemical biological capillary electrophoresis carbon sources catabolism cationic CE/MS chromatogram compounds concentration creatinine culture database deficiency derivatization detection disorders electrospray ionization elution enzyme Escherichia coli ESI-Q-TOF-MS filter paper flow rate fructose FT-ICR-MS GC/MS GEM System gene expression glucose high-performance liquid chromatography HPLC hybrid hyperammonemia identified inborn errors injection intracellular metabolites Kuhara LC/MS lipid malate Mass Spectrom mass spectrometry metabolic pathway metabolic pathway network metabolite profile metabolome metabolome analysis method methylcitrate methylmalonic methylmalonic acidemia mobile phase mode molecular monolithic silica columns MS/MS Nishioka nucleotides organic acids orotate particle-packed columns patients peak phosphate phospholipids procedure propionic acidemia proteins proteomics pyrimidine pyruvate quadrupole quantitative reactions reversed-phase sample screening sensitivity separation silica capillary simulation solution specific spectrum structural substrate subtilis cells tabolome TCA cycle techniques tion Tomita transcriptome trimethylsilyl urease urease pretreatment urinary urine