Metabolomics: The Frontier of Systems Biology (Google eBook)

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Springer Science & Business Media, Jun 18, 2006 - Medical - 270 pages
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Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. In the post-genome era, metabolism has taken on new significance for biological scientists: metabolites are the chemical basis of phenotypes that are final expressions of genomic information. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. The authors have been directly involved in the development of all the subject areas, including capillary electrophoresis, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Breakthrough achievements and the future of metabolome studies are described, making this book a valuable source for researchers in metabolomics in diverse fields, such as plant, animal, cellular, microbial, pharmaceutical, medical, and genetic sciences.
  

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Contents

Overview
Part II Analytical Methods for Metabolome Sciences
6
Development and Application of Capillary ElectrophoresisMass Spectrometry Methods to Metabolomics
7
Application of Electrospray Ionization Mass Spectrometry for Metabolomics
25
HighPerformance Liquid Chromatography and Liquid Chromatography Mass Spectrometry Analyses of Metabolites in Microorganisms
36
Metabolome Profiling of Human Urine with Capillary Gas ChromatographyMass Spectrometry
53
Metabolic Profiling by FourierTransform Ion Cyclotron Resonance Mass Spectrometry FTICRMS and Electrospray Ionization Quadrupole TimeOfFl...
75
Metabolome Analysis by Capillary Electrophoresis
91
Metabolomics in Arabidopsis thaliana
141
Lipidomics Metabolic Analysis of Phospholipids
154
Chemical Diagnosis of Inborn Errors of Metabolism and Metabolome Analysis of Urine by Capillary Gas ChromatographyMass Spectrometry
167
Part IV Metabolome Informatics
192
Introduction to the ARM Database Database on Chemical Transformations in Metabolism for Tracing Pathways
193
The GenomeBased ECELL Modeling GEM System
211
Hybrid DynamicStatic Method for LargeScale Simulation of Metabolism and its Implementation to the ECELL System
221
Part V Metabolomics and Medical Sciences
233

HighPerformance Liquid Chromatography for Metabolomics HighEfficiency Separations Utilizing Monolithic Silica Columns
107
Part III Applications of Metabolome Analysis to Biosciences
127
Combined Analysis of Metabolome and Transcriptome Catabolism in Bacillus subtilis
127
Metabolomics and Medical Sciences
234
Index
245
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