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50 kg Body acetaminophen activities acute painful episodes addiction adjuvant medications adolescents American Pain Society analgesia analgesic appropriate Associate Professor Associated with Sickle-Cell Ballas behavioral Biofeedback breakthrough pain Brief Pain Inventory cancer pain Charache Children's Hospital chronic pain Clinical Practice Guidelines clinicians Codeine cognitive Comprehensive Sickle Cell coping dose of opioid drug emergency department equianalgesic dose factors fentanyl frequent healthcare hepatic Hydrocodone hydromorphone interventions Intravenous Jacox ketorolac management of sickle MD Director Medicine meperidine mg q mg/kg q mood morphine nausea NSAIDs Nursing Ohene-Frempong opioid agonists Opioid Analgesics opioid doses oral opioid Oxycodone pain intensity pain management pain relief Panel consensus parenteral Patient-controlled analgesia pharmacological PhD RN physiological Program psychological psychosocial recommendations relaxation rescue doses respiratory depression response scale scientific evidence sedation severe pain Shapiro sickle cell crisis sickle pain sickle-cell disease sickle-cell pain side effects studies Table techniques tion titration tolerance University Usual Starting Doses vaso-occlusion