Heme Oxygenase: Clinical Applications and Functions
his book provides a comprehensive summary of data from basic research on characterization, regulation, and function of heme oxygenase in mammalian systems. The book also includes a major section that covers the currently used clinical methods to suppress neonatal jaundice with emphasis on the newly developed use of synthetic metalloporophyrins. This book will be welcomed by researchers and students in pharmacology, biochemistry, pharmacy, neonatology, hematology, internal medicine, and endocrinology.
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Porphobilinogen Deaminase and Uroporphyrinogen III Synthetase
Enzymatic Degradation of Heme by Heme Oxygenase
Role of NADPHCytochrome P450 Reductase in Regulation
Mechanisms of Heme Oxygenase Regulation
Toxicity of Bilirubin to the Newborn
Possible Physiological Importance of Bilirubin
6-aminolevulinate Acad adrenals ALA synthetase albumin amino acid bile pigments bilirubin biliverdin reductase binding Biochem Biol Biophys biosynthesis bromobenzene carbon monoxide catabolism cDNA cells cellular Chem Clin cobalt complex concentration cytochrome P-450 detected effect enzymatic enzyme enzyme activity excretion formation fraction glutathione haem heat shock heme degradation heme metabolism heme molecule heme oxygenase activity heme oxygenase isozymes hemin hemoglobin hemopexin hemoproteins hepatic hepatocytes HO-1 gene HO-1 mRNA hyperbilirubinemia hyperthermia Increase Increase Increase induction of heme inhibition isomers isozymes Kappas kidney Kutty liver Rat liver macrophages Maines mammalian mechanism metal ions metalloporphyrins microsomal microsomal heme oxygenase mitochondria molecular weight mouse mRNA NADPH NADPH-cytochrome P-450 reductase Natl neonatal newborn nucleotides oxidation oxygen Pharmacol porphyrin Proc production protein protoporphyrin purified rat brain rat HO-1 Rat liver Decrease Rat liver Rat regulation of heme regulatory sequence serum bilirubin Sn-protoporphyrin specific spleen studies substrate synthesis testis tissue Trakshel transcription factor vivo Yoshida