Mitochondrial Biology: New Perspectives (Google eBook)

Front Cover
Novartis Foundation
John Wiley & Sons, Oct 22, 2007 - Science - 254 pages
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With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail.

Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinsonís, Huntingtonís and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.

  

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Contents

NEW PERSPECTIVES Chairs introduction
1
NEW PERSPECTIVES Outer mitochondrial membrane protein degradation by the proteasome
4
NEW PERSPECTIVES PAGFP a window into the subcellular adventures of the individual mitochondrion
21
NEW PERSPECTIVES Multiple functions of mitochondriashaping proteins
47
NEW PERSPECTIVES Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators
60
NEW PERSPECTIVES Novel uncoupling proteins
70
NEW PERSPECTIVES Mitochondria as generators and targets of nitric oxide
92
NEW PERSPECTIVES Calcium signalling and mitochondrial motility
105
NEW PERSPECTIVES Mitochondrial ion channels in cardiac function and dysfunction
140
NEW PERSPECTIVES The mitochondrial permeability transition pore
157
NEW PERSPECTIVES Mechanisms of mitochondrial outer membrane permeabilization
170
NEW PERSPECTIVES Mitochondria and neurodegeneration
183
NEW PERSPECTIVES Mitochondrial dysfunction in mammalian ageing
197
NEW PERSPECTIVES Mitochondrial mutations genotype to phenotype
214
NEW PERSPECTIVES Contributor Index
234
NEW PERSPECTIVES Subject Index
236

NEW PERSPECTIVES Endoplasmic reticulummitochondria calcium crosstalk
122

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About the author (2007)

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.†

Chairman: David G Nicholls, Buck Institute for Age Research, Novato, USA.

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