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3MSE AChE activity ADAS-cog aggressive behaviors Alzheimer disease Alzheimer's disease amyloid anti-inflammatory ApoE apolipoprotein assessment associated baseline brain Ca2+ carbamazepine Cerebrolysin ChEI cholinergic cholinesterase inhibitors CIBIC-Plus clinical trials cognitive decline cognitive function control group correlation cortex cortical criteria decrease deficits delirium demented dementia depression diagnosis disorders donepezil drugs effects efficacy elderly estrogen euros evaluated family caregivers fMRI geriatric global glutamate Health hippocampal improvement increase inhibition intervention Key words levels lipoproteins markers measures melatonin Memantine metrifonate microglia Mild Cognitive Impairment MMSE neurodegeneration Neurology neurons nicotinic normal aging Notch NSAID nursing home nutritional onset outcome oxidation pathology patients performance placebo plaques predictors Presenilin processes protein Psychiatry receptor risk factors rivastigmine sample schizophrenia score Serdi significant significantly sleep special care unit subjects suggest symptoms synaptic tacrine tasks tests therapeutic therapy treatment vascular wandering week weight loss Wesnes