Red Blood Cell Membranes: Structure: Function: Clinical Implications

Front Cover
Peter Agre
CRC Press, Mar 24, 1989 - Science - 760 pages
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Contents

Recently Identified Erythrocyte MembraneSkeletal
1
New Interactions and Modalities of Regulation
15
Structure and Function of the Glucose Transporter
31
Evolutionary Aspects
41
Intermediate Filament Expression in Erythroid Differentiation
47
Assembly of Vimentin Filaments from a Soluble
55
Expression of Vimentin Filaments from Transfected
63
The Erythrocyte Cytoskeleton in Hereditary Elliptocytosis
77
Albumin pH and Red Blood Cell Shape
407
The Bilayer Couple Hypothesis
409
The Protein GelLipid Bilayer Hypothesis
410
II
411
A Speculative Hypothesis Based on the Duplex Bilayer Model
412
The Spectrin Net
416
Conclusion
418
Viscoelastic Properties and Rheology
423

Hereditary Spherocytosis
97
Conclusion
104
Spectrin Genes
111
NaKATPase Structure
135
NaKATPase a Subunit Isoforms
147
Structure of the 7 Subunit
155
Characterization of the Gene Coding for Human
167
Primary and Secondary Structure of Protein 4 1
173
Summary
183
Association of Protein 4 1 with Glycophorin
192
There Are Two Protein 4 1 Binding Receptors
199
A Phosphoinositide Is a Cofactor for Glycophorin
205
Interaction of Native and Denatured Hemoglobins with
237
Interaction of Denatured Hemoglobin with
244
Ultrastructure and Function of Membrane Skeleton
261
Ultrastructure of Intact Skeletons
273
Conclusion and Future Perspectives
289
The Biochemistry of the Antigens of the
299
The Glycoprotein Antigens
305
Conclusions
314
The Transferrin Receptor
325
Receptor Pools
333
Posttranslational Modification and Factors Controlling Receptor Synthesis
334
Regulation of the Synthesis of Transferrin Receptors
336
Acute Up and Downregulation of the Transferrin Receptor
337
Transferrin Receptors and the Development of Erythroid Cells
339
The Transferrin Receptor and Reticulocyte Maturation
340
The Transferrin Receptor in Diagnosis and Medicine
349
The Transferrin Receptor and Cell Differentiation
350
References
351
Red Blood Cell Membrane Protein and Lipid Diffusion
367
Models of Membrane Protein and Lipid Diffusion
369
Measurements of Membrane Protein and Lipid Diffusion
372
Band 3 and Glycophorin Diffusion
378
Phospholipid and Cholesterol Diffusion
389
Conclusion and Future Prospects
391
References
392
Red Blood Cell Shape
401
I
402
Bending or Shear?
403
The Source of Membrane Bending Resistance
406
Structural Implications
443
Active Transport of Sodium and Potassium
455
HI Regulation of the Sodium Pump
473
The Red Blood
481
Anticalmodulin Agents as Inhibitors of
487
Passive Cation Transport
507
CalciumDependent K Channel The Gardos Pathway
525
Passive Calcium Movements and CaNa Exchange
533
Anion Transport
563
Characteristics of Band 3 Transport
574
Clinical Implications
589
The Kinetics and Thermodynamics of Glucose Transport
597
Inhibition of Glucose Transport
613
Irreversible Inhibitors
620
Conclusion
628
Nucleoside Transport
635
Not All Erythrocytic Nucleoside Transport Systems
644
Sensitivity to NBMPR Are Differentially Sensitive to Nonpenetrating Thiol Reagents
647
Exploration of the Molecular Properties of Erythrocyte Nucleoside Transport Systems with Nucleoside Transport Inhibitors
648
Conclusion
653
References
654
The Response of Ion Transport Pathways to Physiological Stimuli
663
Ion Transport Regulated by Changes in Cell Volume
664
CatecholamineStimulated Ion Transport
678
Other Physiological Effectors of Ion Transport
683
K + CI Cotransport in Red Blood Cell Disorders
684
Summary
685
Notation
686
Ion Transport in Red Blood Cell Disorders
691
The Hemoglobin CC Erythrocyte
697
The Stomatocyte
698
References
700
Partial Deficiencies of Erythrocyte Spectrin in Hereditary Spherocytosis
707
Spherocytosis in Mice
708
Recessive Spherocytosis in Humans
710
Dominant Spherocytosis in Humans
717
Genetic Defects Resulting in Spectrin Deficiency
719
Pathogenesis of Spherocytosis Membranes
721
References
724
Index
727
Copyright

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