Molecular Biology and Pathogenicity of Mycoplasmas

Front Cover
Shmuel Razin, Richard Herrmann
Springer Science & Business Media, Jun 30, 2002 - Medical - 572 pages
was the result of the efforts of Robert Cleverdon. The rapidly developing discipline of molecular biology and the rapidly expanding knowledge of the PPLO were brought together at this meeting. In addition to the PPLO specialists, the conference invited Julius Marmur to compare PPLO DNA to DNA of other organisms; David Garfinkel, who was one of the first to develop computer models of metabolism; Cyrus Levinthal to talk about coding; and Henry Quastler to discuss information theory constraints on very small cells. The conference was an announcement of the role of PPLO in the fundamental understanding of molecular biology. Looking back 40-some years to the Connecticut meeting, it was a rather bold enterprise. The meeting was international and inter-disciplinary and began a series of important collaborations with influences resonating down to the present. If I may be allowed a personal remark, it was where I first met Shmuel Razin, who has been a leading figure in the emerging mycoplasma research and a good friend. This present volume is in some ways the fulfillment of the promise of that early meeting. It is an example of the collaborative work of scientists in building an understanding of fundamental aspects of biology.
 

Contents

Taxonomy of Mollicutes
1
Phylogeny and Evolution
31
Mycoplasmas of Humans
45
Mycoplasmas of Animals
73
Mycoplasmas of Plants and Insects
91
Cell Division
117
The Cell Membrane and Transport
131
Metabolic Flexibility
163
Extrachromosomal Elements and Gene Transfer
347
RestrictionModification Systems and Chromosomal
371
PATHOGENESIS
388
Apoptotic Antiapoptotic Clastogenic and Oncogenic Effects
403
Genetic Mechanisms of Surface Variation
417
Artifacts Facts and Active
445
Cytadherence and the Cytoskeleton
491
xiii
518

Database Systems for the Analysis of Biochemical Pathways
201
Mycoplasmas and the Minimal Genome Concept
221
Comparative Genome Analysis of the Mollicutes
255
Transcriptome and Proteome Analysis of Mollicutes
279
DNA Replication Repair and Stress Response
303
Transcription and Translation
323
Mycoplasma pneumoniae Disease Manifestations
519
Diagnosis of Mycoplasmal Infections
531
Antimycoplasmal Agents
545
Index
567
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