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Saying the truth, this book could be better. Unfortunately, Google gave me a limited time to look through it and I have to rely on my first impression. I think, the book is adequate to what we used to know about MMPs and their inhibitors 10-15 years ago. However, you have to find something else if collection of antique artifacts is not your primary goal in Science. There is some progress made lately and this book simply does not reflect it. I feel deceived and disappointed. Perhaps, I will find something better.
ACE inhibitors acetazolamide active site adduct affinity agents amino acid analogues aromatic atom bacterial bicarbonate Biochem Biol Bioorg brinzolamide C-domain C-terminal C. T. Carbonic anhydrase CAIs cancer Carbonic anhydrase inhibitors carboxylate catalytic domain cell Chem clinical collagen collagenase complex compounds coordination crystal structure cytosolic derivatives DHOase drug design effects enzyme extracellular farnesyltransferase inhibitors FIGURE function GCPII gene HCO3À HDAC histidine human carbonic anhydrase hydrogen bond hydrophobic inhibition inhibitory activity interaction isoforms isozymes Lett leuc-B ligand matrix metalloproteinase mechanism membrane metal ion methazolamide MMP inhibitors MMPI MMPs moiety molecular molecule NaOH Bidentate novel Parkkila Pastorek peptide potent protease protein proton QSAR residues role Scozzafava selective sequence studies substrate sulfamate sulfamide sulfonamides Supuran synthesis TACE target therapeutic therapy tissue topiramate tumor tumor-associated Winum X-ray zinc zinc binding zinc ion Zn(II Zn2þ