Allergic Contact Dermatitis: The Molecular Basis
Springer, 1998 - Medical - 186 pages
Allergic Contact Dermatitis presents all up-to-date chemical and physio-chemical concepts for the study and understanding of allergic contact dermatitis (ACD). The book covers all aspects of ACD - skin penetration and metabolism, identification of sensitizers and hapten-protein interaction, including new concepts of increasing importance such as molecular recognition and quantitative structure-activity relationships. In addition, comprehensive references are provided, making this the most complete available text-book for dermatologists.
Allergic Contact Dermatitis reaches an equilibrium between fundamental concepts and clinical applications and thus presents an essential guideline to dermatologists, allergologists, biochemists and toxicologists.
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Isolation and Identification of Contact Allergens
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abietic acid alkyl allergenic activity allergic contact dermatitis allylglycidylether amino analysis antigen antigen-presenting cells atom Basketter Benezra binding biological budesonide carbon Chem Res Toxicol chemical reactivity chemical structure chromatography class-II colophony colophony components compounds contact allergens corticosteroids covalent bonds cross-reactions cytochrome P-450 cytokines d-limonene dehydroabietic acid DEREK derivatives detected electrons electrophilic enzymes epidermal epoxides esters eugenol example formaldehyde formation geometry guinea pig hapten HPLC hydroperoxides hydrophobicity identified immune Immunol induced interaction Invest Dermatol isoeugenol Karlberg A-T keratinocytes Langerhans cells Lepoittevin LLNA logP lymph node lymphocytes metabolism methyl microsomes molecular molecules nickel Nilsson JLG NO2 NO2 nucleophilic substitution orbitals oxidation P-450 isoenzymes paper parameters patch test patients peptides phase phenolic predict protein QSAR quantitative radical react receptor resin acids response Roberts DW rosin sensitisation potential skin sensitisation SN2 reaction solvent structural alerts studies sultones tion unsaturated urushiol
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