A Statistical Approach to Genetic Epidemiology: Concepts and Applications, with an e-learning platform

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John Wiley & Sons, May 24, 2010 - Science - 522 pages
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This is the second edition of the successful textbook written by the prize-winning scientist Andreas Ziegler, former President of the German Region of the International Biometric Society, and Inke R. König, who has been teaching the subject over many years.

The book gives a comprehensive introduction into the relevant statistical methods in genetic epidemiology. The second edition is thoroughly revised, partly rewritten and includes new chapters on traditional family studies and state-of-the-art genome-wide association studies. The book is ideally suited for advanced students in epidemiology, genetics, statistics, bioinformatics and biomathematics. Like in the first edition, the book contains many problems and solutions. 

E-learning Platform Edition:
The paperback version of this book exclusively comes with an e-learning course created by Friedrich Pahlke. This e-learning course has been developed to complement the book and both provide a unique support tool for teaching the subject.

  

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Contents

Formal Genetics
21
Genetic Markers
47
Data Quality
67
Genetic Map Distances
113
Family Studies
125
xx
155
ModelFree Linkage Analysis
189
Quantitative Traits
221
Association Analysis in Unrelated Individuals
265
Familybased Association Analysis
319
Haplotypes in Association Analyses
349
Genomewide Association GWA Studies
367
Appendix
393
Solutions
415
References
451
Index
489

Fundamental Concepts of Association Analyses
247

Common terms and phrases

About the author (2010)

After studying statistics and mathematics at the University of Munich and obtaining his doctoral degree from the University of Dortmund, Andreas Ziegler received the Johann-Peter-Su?milch-Medal of the German Association for Medical Informatics, Biometry and Epidemiology for his post-doctoral work on "Model Free Linkage Analysis of Quantitative Traits" in 1999. In 2004, he was one of the recipients of the Fritz-Linder-Forum-Award from the German Association for Surgery. Andreas Ziegler is head of the Institute for Medical Biometry and Statistics at the University Clinic Schleswig-Holstein in Lubeck, an acknowledged center of excellence for genetic epidemiological methods. Currently he is President of the German Region of the International Biometric Society.

Inke R. Konig studied psychology at the universities of Marburg (Germany) as a scholar of the German National Academic Foundation and Dundee (Scotland) with a grant from the German Academic Exchange Service (DAAD). She has done research work at the Institute of Medical Biometry and Epidemiology in Marburg and since 2001 at the Institute of Medical Biometry and Statistics in Lubeck. In 2004, she became vice director of the latter and also received the Fritz-Linder-Forum-Award from the German Association for Surgery. Besides holding the certificate "Biometrics in Medicine", she has collected teaching experience since 1998 as a lecturer for biomathematics, behavioural genetics, clinical epidemiology, genetic epidemiology, and evidence-based medicine.

Friedrich Pahlke is Dipl. Inf. at the Institute for Medical Biometry and Statistics at the University Clinic Schleswig-Holstein in Lubeck. He has created the e-learning course which is optionally available with the book.

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