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acid activity addition afferent alveolar bone antibodies antigens Arch associated calcification calcitonin calcium cartilage cellular cementum changes collagen complex component comprises connective tissue cranial craniofacial deficiency deglutition Dent dental plaque dentine effects enamel endothelial enzymes epithelial epithelium extracellular facial factors fibres fibroblasts fluid formation function gingival gingival sulcus glands growth hormone increased inflammatory inhibition initial insulin interaction ions layer leucocytes lymphocytes macrophages mandible mandibular masticatory matrix mechanisms membrane mesenchymal metabolism micro-organisms microbial migration mineral muscle nerve neural crest cells neurones nucleus occlusal occur odontoblasts Oral Biol oral cavity oral mucosa orthodontic osteoclasts osteocytes pain palate parathyroid parathyroid hormone periodontal disease periodontal ligament periodontium pharyngeal phase phosphate plasma production protein pulp reactions receptors reflex region response result Review questions saliva salivary secretion secretory sensory skeletal stimulation surface syndrome synthesis taste buds teeth thyroid tion tongue tooth eruption tooth movement trigeminal vascular vitamin whereas wound healing