Treatment-Resistant Mood Disorders

Jay D. Amsterdam, Mady Hornig, Andrew A. Nierenberg

Cambridge University Press, Jun 28, 2001 - Medical - 535 pages

Although antidepressants have helped millions worldwide, a substantial proportion of patients fail to respond or remit. There is little published information available to clinicians for diagnosis and management of treatment-resistant depression, causing them to make difficult decisions regarding treatment options with very limited data. The editors and their internationally distinguished team of contributors have set out to address this problem, giving a critical assessment of all aspects of treatment-resistant depression: causes, epidemiology, comorbidity, evaluation, and treatment. This timely book will be invaluable to clinicians, neuroscientists, researchers, and graduate students.

Contents

• The characterization and definition of treatmentresistant mood disorders: 3
• Overview of treatmentresistant depression and its management: 28
• Biological basis: 45
• Psychoneuroendocrine aspects of treatmentresistant mood disorders: 47
• Estrogen and depressive illness in women: 78
• Sleep abnormalities in treatmentresistant mood disorders: 94
• Structural and functional brain imaging in treatmentresistant depression: 109
• Immunologic factors in treatmentresistant depression: 140
• Treatment approaches: 155
• Selective serotonin reuptake inhibitors and serotoninnorepinephrinereuptake inhibitors in treatmentresistant depression: 157
• Conventional and second generation monoamine oxidase inhibitors in treatmentresistant depression: 178
• Drug combination strategies: 192
• Electroconvulsive therapy in medicationresistant depression: 219
• Thyroid augmentation: 235
• Cognitive therapy and psychosocial interventions in chronic and treatmentresistant mood disorders: 248
• Special patient populations: 267
• Chronic and refractory mood disorders in childhood and adolescence: 269
• Treatmentresistant depression in the elderly: 284
• Management of treatmentresistant depression during pregnancy and the postpartum period: 317
• Preliminary algorithms for treatmentresistant bipolar depression: 346
• Medical disorders and treatmentresistant depression: 401
• Psychiatric comorbidity in treatmentresistant depression: 426
• Suicide in treatmentrefractory depression: 473
• Economic and ethical issues: 483
• The economic impact of treatment nonresponse in major depressive disorders: 485
• Ethical issues in research and treatment of patients with mood disorders: 498
• Index: 511

Bibliographic information

• Title: Treatment-Resistant Mood Disorders
• Editors: Jay D. Amsterdam, Mady Hornig, Andrew A. Nierenberg
• Edition: illustrated, reprint
• Publisher: Cambridge University Press, 2001
• ISBN: 0521593417, 9780521593410
• Length: 535 pages
• Subjects: Medical / Mental Health; Medical / Psychiatry / General; Psychology / Clinical Psychology; Psychology / Psychopathology / Depression