The fat-rich diet typical of Western society contributes to high rates of coronary heart disease, which is the most common cause of death from middle age onwards in much of the developed world. Yet many recent trials have clearly shown that lipid-lowering drugs can reduce the risk of such disease and stroke, and increase life expectancy. Using an evidence-based approach. Fast Facts -- Hyperlipidemia provides a rationale and practical guidance for healthcare professionals in the clinical management of hyperlipidemias.
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adipose tissue apoB apoB level apoE apolipoprotein atherogenic atheroma atherosclerosis atorvastatin ATPIII Betteridge DJ CHD risk cholesteryl ester chylomicrons circulation clinical trials combined hyperlipidemia coronary disease coronary heart disease decrease dense LDL particles diabetes mellitus diagnosis diet dietary Durrington PN effect elevated apoB enzyme familial fatty acid trapping fibrate Figure foam cells hepatic heterozygotes heterozygous FH homozygous FH hyperlipoproteinemia hypertension hypertriglyceridemia increased insulin resistance LDL cholesterol LDL cholesterol levels LDL particle number LDL receptor lesions levels of LDL lipid lipid-lowering lipoprotein lipase Lipoproteins in Health liver low HDL cholesterol lower Lp(a measurement metabolism mg/dL mmol/L NON-SMOKER SMOKER normal obesity occur oxidation P-blockers pancreatitis particularly phospholipids plasma polygenic hypercholesterolemia primary prevention protein reduced remnants renal risk factors secondary prevention Serum HDL severe hypertriglyceridemia statin statin therapy Study syndrome target tendon xanthomata total cholesterol treatment triglycerides type 2 diabetes type III hyperlipoproteinemia vascular disease VLDL VLDL secretion xanthomata