Medicinal Applications of Coordination Chemistry
Metals in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for a number of different applications, the design of new drugs and the relationship between structure and function. Key sections include diagnostic applications of metal compounds in anatomical and functional imaging, and therapeutic applications of metals compounds. This book is ideal for researchers in academia and industry and comes complete with examples of real life applications.
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The Chemistry of Metals in a Nutshell
acid activity adducts antibody anticancer antitumor applications aqueous behaviour bifunctional agents biological bleomycin blood bonding bone cancer carboxylate cell charge chelating chelation therapy chemical chloride cisplatin Cl Cl clinical compounds containing contrast agents coordination chemistry covalent crystal ﬁeld d-block d-block metal deﬁned diagnostic dioxygen donor atoms dose drugs effect efﬁcient electron conﬁguration elements energy enzyme example excretion Figure ﬁlled ﬁrst formation hydrogen hydrolysis imaging agents important interaction involves ionic iron kg└1 labelled labile lanthanide ligand ligand structure lipophilic liver magnetic metal binding metal centre metal complexes metal ion metallopharmaceuticals MRI contrast agents octahedral orbitals oxidation number oxygen platinum proligand properties protein proton radiation radionuclide radiopharmaceutical reaction reactive redox reduced ruthenium similar solubility speciﬁc stability constants subshell substituents sufﬁciently symmetry target technetium therapeutic therapy tissue toxicity tumor uptake valence shell vanadium vivo water molecule