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affective disorders age of onset agitated amitriptyline anxiety group anxious depressive basis behavior bimodal distribution bipolar factor bipolar patients canonical variate analysis classification of depressive classified depressive clinical cluster analysis compared component composite scores concluded continuum correlations depressed patients depressive disorders depressive entities depressive groups depressive illness depressive items diagnostic categories diagnostic entities diagnostic groups differentiate discriminant function analysis distribution of scores endogenous depression etiology excretion factor analysis factor scores factor that contrasted factor-analytic findings guilty depression hostile depression imipramine indicated involutional involutional melancholia Kiloh large number mania manic manic-depressive Mendels MHPG neurotic depression nondepressed normal distribution original diagnosis physiological Pilowsky principal component analysis psychiatric psychotic depression ratings reactive depression replication retarded depression Roth sample of depressed separate severity of depression severity of illness significant single somatic statistical classification statistical methods subgroups suggested symptom patterns syndrome technique thioridazine unimodal unipolar and bipolar unipolar depression validation variables