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abnormalities acid Acta activity acute agents agranulocytosis anemia Ann Intern antibodies anticoagulant antigen antithrombin Arch Intern assay associated bleeding blood bone marrow Cancer Chapter chronic Clin Invest Clin Pathol clinical coagulation factors congenital defect deficiency diagnosis doses drugs effect Engl enzyme eosinophilia factor IX factor VII deficiency factor VIII fibrin fibrinogen fibrinolysis gene granulocyte Haematol hemophilia hemorrhagic heparin hepatic hereditary histiocytosis idiopathic thrombocytopenic purpura immune immunodeficiency immunoglobulin immunologic increased infection infectious mononucleosis inhibition inhibitors intravascular coagulation JAMA Lab Clin laboratory Lancet lesions leukemia leukocyte levels liver lupus lymphocytes lymphoma megakaryocytes neutropenia neutrophils normal patients Pediatr plasma platelet aggregation platelet count platelet function produce protein prothrombin reaction result Scand serum spleen splenectomy splenic splenomegaly studies syndrome therapeutic therapy Thromb Haemost Thromb Res thrombin thrombocytopenia thrombocytopenic purpura thrombocytosis thrombosis thrombotic tissue transfusion treatment usually vascular venous viral virus vitamin vitro Willebrand's disease