Cancer Drug Development, Volume 17Vincent T. DeVita (Jr.), Harris Busch |
Contents
TESTING THERAPEUTIC HYPOTHESES IN MICE | 5 |
CHAPTER I | 6 |
Specific Questions Relating to Drug Treatment of Advanced Clinically | 28 |
Copyright | |
31 other sections not shown
Common terms and phrases
achieved activity acute addition agents animals anticancer appear application approach blood body Cancer Cancer Res cells changes chemotherapy combination compared complete compounds concentration concept considered course cure cyclophosphamide DAYS DEATHS demonstrated designed disease dose drug effects et al evaluation evidence example excretion experimental exponential factors given greater growth half-life human important increase indicated individual initial less leukemia levels LIMIT major MEDIAN methods methotrexate MG/KG mice normal observed occur organ patients pharmacokinetic Phase Philadelphia physician plasma possible predictive produce randomized clinical trial RANGE ratios regression relatively remission reported response schedule selected shark showed similar solid tumors SPAN species standard studies Table testing therapeutic therapy tion tissues toxicity treated treatment tumor TUMOR REGRESSION types usually values variable vincristine volume