Methodology for Genetic Studies of Twins and FamiliesFew would dispute the truth of the statement `People are Different', but there is much controversy over why. This book authoritatively explains the methods used to understand human variation, and extends them far beyond the primary `nature or nurture' question. After chapters on basic statistics, biometrical genetics, matrix algebra and path analysis, there is a state-of-the-art account of how to fit genetic models using the LISREL package. The authors explain not only the assumptions of the twin method, but how to test them. The elementary model is expanded to cover sex limitation, sibling interaction, multivariate and longitudinal data, observer ratings, and twin-family studies. Throughout, the methods are illustrated by applications to diverse areas such as obesity, major depression, alcohol comsumption, delinquency, allergies, and common fears. |
Contents
List of Tables | xxi |
Chapter 1 | 1 |
a | 6 |
40 | 9 |
Chapter 2 | 35 |
a | 46 |
a | 47 |
Chapter 3 | 55 |
Chapter 13 | 261 |
Chapter 14 | 289 |
Estimated correlations among latent genetic and environmental | 302 |
Chapter 15 | 305 |
Chapter 16 | 313 |
Chapter 17 | 329 |
Chapter 18 | 353 |
Appendix A | 373 |
+d+ | 66 |
Chapter 4 | 71 |
V | 75 |
Chapter 5 | 87 |
i Single indicator variable model | 108 |
Chapter 6 | 109 |
Chapter 7 | 131 |
is a vector of the elements in the lower half | 135 |
Chapter 8 | 149 |
Chapter 9 | 189 |
Chapter 10 | 199 |
Chapter 11 | 211 |
Chapter 12 | 231 |
Appendix B | 381 |
Appendix C | 383 |
Appendix D | 397 |
Appendix E | 399 |
Appendix F | 413 |
Appendix G | 415 |
Appendix H | 437 |
Appendix I | 445 |
Appendix J | 453 |
Appendix K | 459 |
| 463 | |
| 485 | |
Other editions - View all
Methodology for Genetic Studies of Twins and Families Michael Neale,Lon Cardon No preview available - 1992 |
Methodology for Genetic Studies of Twins and Families Michael Neale,Lon Cardon No preview available - 2010 |
Common terms and phrases
AD=OFF additive genetic additive genetic effects alcohol assortative mating Behavior Genetics biometric model biometrical bivariate Body Mass Index causal causation model Chapter chi-squared common constraints correlation matrix covariance matrix degrees of freedom dependent variables diagonal differences dominance genetic DZ pairs DZ twins Eaves environmental effects EQ LX example expected covariance factor loadings factor model female Figure fit function genes genetic and environmental genetic effects genetic model genotype hypotheses influence latent variables LISREL model LISREL script MA=CM male means measurement error model fitting multivariate MZ and DZ observed variables parameter estimates parents path analysis path coefficients path diagram polychoric PRELIS reciprocal causation regression sample shared environment shared environmental simplex model specific statistics structural equation structural equation modeling Table trait twin data twin groups twin pairs twin study Twin1 Twin2 univariate values variance components variances and covariances variation weight zero zygosity
Popular passages
Page ii - Advanced Science Institutes Series A series presenting the results of activities sponsored by the NATO Science Committee, which aims at the dissemination of advanced scientific and technological knowledge, with a view to strengthening links between scientific communities The series is published by an international board of publishers in conjunction with...
Page 471 - Interactive Effects of Genotype and Social Environment on Alcohol Consumption in Female Twins.
Page 475 - Kessler, RC, Kendler, KS, Heath, A., Neale, MC, & Eaves, LJ (1992). Social support, depressed mood, and adjustment to stress: A genetic epidemiologic investigation.