Methodology for Genetic Studies of Twins and Families
Michael Neale, Lon Cardon
Springer Science & Business Media, Jul 31, 1992 - Medical - 496 pages
Few would dispute the truth of the statement `People are Different', but there is much controversy over why. This book authoritatively explains the methods used to understand human variation, and extends them far beyond the primary `nature or nurture' question. After chapters on basic statistics, biometrical genetics, matrix algebra and path analysis, there is a state-of-the-art account of how to fit genetic models using the LISREL package.
The authors explain not only the assumptions of the twin method, but how to test them. The elementary model is expanded to cover sex limitation, sibling interaction, multivariate and longitudinal data, observer ratings, and twin-family studies. Throughout, the methods are illustrated by applications to diverse areas such as obesity, major depression, alcohol comsumption, delinquency, allergies, and common fears.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Path Analysis and Structural Equations
LISREL Models and Methods
Model Fitting Functions and Optimization
Assortment and Cultural Transmission
B The Greek Alphabet
LISREL Script for Power Calculation
F LISREL Script for Sibling Interaction Model
G LISREL Scripts for Sex and GxE Interaction
Power and Sample Sice
Sexlimitation and G x E Interaction
I3 Direction of Causation
Longitudinal Mean Trends
additive genetic effects assortative mating behavior biometric model biometrical bivariate body mass index causal causation model Chapter chi-squared common compute constraints covariance matrix degrees of freedom dependent variables diagonal differences DZ pairs DZ twins elements Email environmental effects EQ LX example expected covariance factor loadings factor model Figure fit function free parameters genes genetic and environmental genetic model genotype goodness-of-fit hypotheses influence latent factors latent variables like-sex LISREL model LISREL script MA=CM male maximum likelihood means measurement error methods MO NY=2 model fitting multiple multivariate MZ and DZ NS AD=OFF observed variables parameter estimates parents path coefficients path diagram PH=SY,FI polychoric PRELIS random ratings reciprocal causation regression sample shared environment shared environmental simplex model specific statistics structural equation modeling Table trait twin data twin groups twin pairs twin study Twin2 Twinl univariate values variance components variances and covariances variation vector weight within-family zero zygosity
Page viii - Advanced Science Institutes Series A series presenting the results of activities sponsored by the NATO Science Committee, which aims at the dissemination of advanced scientific and technological knowledge, with a view to strengthening links between scientific communities The series is published by an international board of publishers in conjunction with...