Methodology for Genetic Studies of Twins and Families

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Michael Neale, Lon Cardon
Springer Science & Business Media, Jul 31, 1992 - Medical - 496 pages
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Few would dispute the truth of the statement `People are Different', but there is much controversy over why. This book authoritatively explains the methods used to understand human variation, and extends them far beyond the primary `nature or nurture' question. After chapters on basic statistics, biometrical genetics, matrix algebra and path analysis, there is a state-of-the-art account of how to fit genetic models using the LISREL package.
The authors explain not only the assumptions of the twin method, but how to test them. The elementary model is expanded to cover sex limitation, sibling interaction, multivariate and longitudinal data, observer ratings, and twin-family studies. Throughout, the methods are illustrated by applications to diverse areas such as obesity, major depression, alcohol comsumption, delinquency, allergies, and common fears.
  

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Contents

Data Summary
35
Biometrical Genetics
55
Matrix Algebra
71
Path Analysis and Structural Equations
87
LISREL Models and Methods
109
Model Fitting Functions and Optimization
131
Univariate Analysis
149
the Australian Twin Register
151
Observer Ratings
313
Assortment and Cultural Transmission
329
Future Directions
353
APPENDICES
373
B The Greek Alphabet
381
LISREL Script for Power Calculation
397
F LISREL Script for Sibling Interaction Model
413
G LISREL Scripts for Sex and GxE Interaction
415

Power and Sample Sice
189
Social Interaction
199
Sexlimitation and G x E Interaction
211
Multivariate Analysis
231
I3 Direction of Causation
261
Repeated Measures
289
Longitudinal Mean Trends
305
H LISREL Script for Rater Bias Model
437
LISREL Scripts for Direction of Causation
445
J LISREL Script and Data for Simplex Model
453
K LISREL Scripts for Assortment Models
459
Index
485
Copyright

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Page viii - Advanced Science Institutes Series A series presenting the results of activities sponsored by the NATO Science Committee, which aims at the dissemination of advanced scientific and technological knowledge, with a view to strengthening links between scientific communities The series is published by an international board of publishers in conjunction with...
Page 477 - Interactive Effects of Genotype and Social Environment on Alcohol Consumption in Female Twins.
Page 481 - Kessler, RC, Kendler, KS, Heath, A., Neale, MC, & Eaves, LJ (1992). Social support, depressed mood, and adjustment to stress: A genetic epidemiologic investigation.

References to this book

Statistics in Human Genetics
Pak Sham
No preview available - 1998
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About the author (1992)

Cardon is Professor of Bioinformatics, Wellcome Trust Centre for Human Genetics, University of Oxford.

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