Oxygen and Life: Oxygenases, Oxidase, and Lipid Mediators : Proceedings of the 3rd International Conference on Oxygen and Life which was Held in Kyoto, Between 26 and 29 November 2000

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Yuzuru Ishimura
Elsevier, 2002 - Medical - 560 pages
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These proceedings cover recent advances in research on "Oxygenases and oxygen metabolism" and have been dedicated to Professor Osamu Hayaishi, the discoverer of dioxygenase.

Humans inhale and exhale molecular oxygen (O2), and cannot live without it. Oxygenases are the enzymes, which catalyze the fixation of either one or two atoms of molecular oxygen into a wide variety of substrates including steroid hormones, eicosanoids, amino acids, drugs, toxic substances and carcinogens. Many of the substrates and metabolic products of oxygenases show remarkable biological effects on cellular activities. They usually act to maintain homeostasis of the cell and hence to keep the organism healthy.

These proceedings describe: (1)Molecular properties and mechanism of action of oxidases and oxygenases including x-ray structures of cytochrome c oxidase, cytochromes P450 and other kinds of mono- and dioxygenases. (2)How oxygenases and their metabolites are effective in keeping the cells healthy, and why they are sometimes harmful. (3) The state of the art in research on the cellular action of eicosanoids.

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