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acute administration adrenal adrenergic aldosterone angio angiotensin III animals antihypertensive aorta arterial pressure arterioles authors concluded beta-adrenergic blood pressure caused changes Circ Res circulating Clin Sci Mol clonidine converting enzyme correlated cortical decrease disease dogs doses effects of angiotensin elevated essential hypertension ﬂuid furosemide glomerular granules hemodynamic hormone hyper hypertensive patients hypotensive increase in plasma indomethacin induced inﬂuence infusion inhibition inhibitor intravenous juxtaglomerular apparatus kidney lesions macula densa mechanism mediated nephrectomy nervous system norepinephrine normotensive pathogenesis patients with essential peptide perfusion peripheral Physiol plasma aldosterone plasma renin activity plasma renin concentration potassium propranolol prostaglandin rabbit receptors renal artery stenosis renal blood ﬂow renal failure renal hypertension renal vein renal vein renin renin essential hypertension renin levels renin release renin secretion renin substrate renin-angiotensin system renovascular hypertension reported role saralasin serum sodium sodium depletion sodium excretion spironolactone stimulation suggest suppression syndrome tension tissue treatment urinary venous