Immunological Bioinformatics

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Ole Lund
MIT Press, 2005 - Computers - 296 pages
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Despite the fact that advanced bioinformatics methodologies have not been used as extensively in immunology as in other subdisciplines within biology, research in immunological bioinformatics has already developed models of components of the immune system that can be combined and that may help develop therapies, vaccines, and diagnostic tools for such diseases as AIDS, malaria, and cancer.In a broader perspective, specialized bioinformatics methods in immunology make possible for the first time a systems-level understanding of the immune system. The traditional approaches to immunology are reductionist, avoiding complexity but providing detailed knowledge of a single event, cell, or molecular entity. Today, a variety of experimental bioinformatics techniques connected to the sequencing of the human genome provides a sound scientific basis for a comprehensive description of the complex immunological processes.This book offers a description of bioinformatics techniques as they are applied to immunology, including a succinct account of the main biological concepts for students and researchers with backgrounds in mathematics, statistics, and computer science as well as explanations of the new data-driven algorithms in the context of biological data that will be useful for immunologists, biologists, and biochemists working on vaccine design. In each chapter the authors show interesting biological insights gained from the bioinformatics approach. The book concludes by explaining how all the methods presented in the book can be integrated to identify immunogenic regions in microorganisms and host genomes.

  

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Contents

Immune Systems and Systems Biology
1
Contemporary Challenges to the Immune System
17
Sequence Analysis in Immunology
35
Methods Applied in Immunological Bioinformatics
69
DNA Microarrays in Immunology
103
Prediction of Cytotoxic T Cell MHC Class I Epitopes
111
Antigen Processing in the MHC Class I Pathway
135
Prediction of Helper T Cell MHC Class II Epitopes
157
Processing of MHC Class II Epitopes
175
B Cell Epitopes
187
Vaccine Design
203
WebBased Tools for Vaccine Design
215
MHC Polymorphism
223
An Integrative Approach
243
Index
291
Copyright

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Page 275 - Morel, S., Levy, F, Burlet-Schiltz, O., Brasseur, F, Probst-Kepper, M., Peitrequin, AL, Monsarrat, B., Van Velthoven, R., Cerottini, JC, Boon, T., Gairin, JE, and Van den Eynde, BJ (2000).
Page 288 - T cell recognition as the target for immune intervention in autoimmune disease. Cell 57:709-715, 1989 4.
Page 267 - KR (1981) Prediction of protein antigenic determinants from amino acid sequences. Proc. Nati. Acad. Sci. USA 78, 3824-3828.

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About the author (2005)

Ole Lund is Associate Professor and leader of the Immunological Bioinformatics group at the Center for Biological Sequence Analysis at Technical University of Denmark.

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