Tissue and Organ Regeneration in Adults
The emphasis throughout this volume is on the systematic development of the viewpoint that regeneration is an instance of synthesis of tissues and organs. This has three simple consequences. The first is the requirement for a special kind of experimental reactor, free of tissues that do not regenerate spontaneously. The second calls for meticulous physicochemical and biological characterization of the end products from such a synthetic reaction. The third calls for the required use of appropriate non-diffusible regulators in the experimental reactor. These insoluble matrices induce adult cells to abandon their normal proclivity in closing up adult wounds in exchange for synthesizing physiological tissues. This approach is independent of the organ under study. It is developed in substantial depth during the first several chapters by limiting the discussion to just two two organs that are quite different from each other, namely skin and peripheral nerves. The conclusions from this analysis apply to either organ with roughly equal strength. This intriguing result clearly suggests a generic methodology for synthesis of other organs. The book also features an extensive bibliography, and extensive bodies of independent data on organ regeneration from the journal literature have been collected together for the first time and accessibly presented in tabular form, enabling direct comparisons. In short, the generic organ-blind methodology described in this volume should be useful to most students and practitioners of tissue engineering.
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The Irreversibility of Injury
Anatomically WellDefined Defects
The Defect Closure Rule
Regeneration of Skin
Regeneration of a Peripheral Nerve
Irreducible Processes for Synthesis of Skin
adult anchoring fibrils axons basement membrane Chamberlain Chapter collagen fibers collagen tube components comprising configuration contractile cells contraction cultured cytokines defect area defect closure degradation dermal dermis dermis-free defect described distal stump ECM analogs endoneurial stroma endoneurium epidermis epithelial evidence experimental fetal fibroblasts fibronectin function gap length grafted granulation tissue growth factor guinea pig Hansbrough healing process hemidesmosomes hypothetical implantation induced regeneration injury inside investigators KC sheets keratinocytes lamina densa lamina lucida laminin layer matrix mechanism mouse myelin sheath myelinated axons myofibroblasts nerve fibers nerve trunk neuroma nondiffusible regulator normal observed organ Orgill oriented perineurial perineurium peripheral nerves phenotype physiological protocols rat sciatic nerve reactants reaction diagrams regenerative activity repair rete ridges scar synthesis Schwann cells sciatic nerve silicone tube skin and peripheral skin defect skin wound spontaneous healing spontaneous regeneration stroma structure surface Table thickness tion transected nerve type IV collagen vitro vivo Yannas